Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. - Wikidata - awgldk - TriplyDB

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

http://www.wikidata.org/entity/Q34464152

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A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease Genes associated with Alzheimer's disease: an overview and current status Tau Oligomers: The Toxic Player at Synapses in Alzheimer's Disease The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease.AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease Drug combination therapy increases successful drug repositioning.Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes.Academic drug discovery: current status and prospects.Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease.Targeting Fyn Kinase in Alzheimer's Disease.Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.Actin dynamics and cofilin-actin rods in alzheimer disease.Beyond immunotherapy: new approaches for disease modifying treatments for early Alzheimer's disease.Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease.Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.Epileptic activity in Alzheimer's disease: causes and clinical relevance.Emerging treatments for Alzheimer's disease for non-amyloid and non-tau targets.Association of cancer and Alzheimer's disease risk in a national cohort of veterans.Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's disease Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.A c-Src Inhibitor Peptide Based on Connexin43 Exerts Neuroprotective Effects through the Inhibition of Glial Hemichannel Activity.Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.Tau-based therapies in neurodegeneration: opportunities and challenges.Kinetic evaluation and test-retest reproducibility of [(11)C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.Early Activation of Experience-Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease.Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.Emerging Mechanisms in Alzheimer's Disease and Their Therapeutic Implications.

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P2860

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

http://www.wikidata.org/entity/Q34464152

description

2015 nî lūn-bûn

@nan

2015 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

@zh-hk

2015年論文

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2015年論文

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2015年论文

@wuu

name

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@ast

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@en

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@nl

type

label

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@ast

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@en

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@nl

prefLabel

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@ast

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@en

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@nl

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Annals of Neurology

P1476

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

@en

P2093

Adam C Kaufman

http://www.w3.org/2001/XMLSchema#string

Amanda T Jeng

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Christopher H van Dyck

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Erik C Gunther

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Haakon B Nygaard

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Jinhee Yang

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Laura T Haas

http://www.w3.org/2001/XMLSchema#string

Santiago V Salazar

http://www.w3.org/2001/XMLSchema#string

P2860

Tau interacts with src-family non-receptor tyrosine kinases

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

P304

953-971

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scholarly article

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10.1002/ANA.24394

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6

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77

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Stephen M. Strittmatter

Sophie A Robinson

Mikhail A Kostylev

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2015-03-21T00:00:00Z

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272844223

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25707991

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P921

Alzheimer's disease

regulation of synaptic plasticity

Major prion protein

Protein tyrosine kinase 2 beta

Amyloid beta precursor protein

FYN proto-oncogene, Src family tyrosine kinase

P932

4447598

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