Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
about
LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerizationInvolvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesisTranscriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgammaStructural insights into corepressor recognition by antagonist-bound estrogen receptorsSmall Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)Structural insights into gene repression by the orphan nuclear receptor SHPMAFG is a transcriptional repressor of bile acid synthesis and metabolismA PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrileSmall heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptorsRifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human HepatocytesNuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism.Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor αThe nuclear hormone receptor family round the clock.11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.Loss of the orphan nuclear receptor SHP is more pronounced in fibrolamellar carcinoma than in typical hepatocellular carcinoma.Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modificationsLigand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partnerMetformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 geneCoordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo.A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.Epigenetic regulation of drug metabolism and transportLiver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2.Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma.Differential inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by the small heterodimer partner.Regulatory circuits controlling white versus brown adipocyte differentiation.FXR and PXR: potential therapeutic targets in cholestasis.Expressed sequence tags (ESTs) and single nucleotide polymorphisms (SNPs): what large-scale sequencing projects can tell us about ADME.The role of 21-hydroxylase in the pathogenesis of adrenal masses: review of the literature and focus on our own experience.The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP.Nuclear receptors: decoding metabolic diseaseCritical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis.Distinct regulation of hepatitis B virus biosynthesis by peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner in human hepatoma cell lines.Minireview: role of orphan nuclear receptors in cancer and potential as drug targetsNuclear receptors: the controlling force in drug metabolism of the liver?
P2860
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P2860
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@ast
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@en
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@nl
type
label
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@ast
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@en
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@nl
prefLabel
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@ast
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@en
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@nl
P2093
P1476
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences.
@en
P2093
Ann Båvner
Eckardt Treuter
Sabyasachi Sanyal
P304
P356
10.1016/J.TEM.2005.10.005
P577
2005-11-04T00:00:00Z