Overexpression of Fto leads to increased food intake and results in obesity - Wikidata - awgldk - TriplyDB

Overexpression of Fto leads to increased food intake and results in obesity

Overexpression of Fto leads to increased food intake and results in obesity

http://www.wikidata.org/entity/Q34479211

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N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification The bigger picture of FTO: the first GWAS-identified obesity gene Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons Five years of GWAS discovery Recent advances in dynamic m6A RNA modification Role of FTO in Adipocyte Development and Function: Recent Insights Obesity genetics in mouse and human: back and forth, and back again Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies Adult onset global loss of the fto gene alters body composition and metabolism in the mouse Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues Preclinical models for obesity research Modify or die?--RNA modification defects in metazoans Obesity-associated variants within FTO form long-range functional connections with IRX3 Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context Inhibition of 2-oxoglutarate dependent oxygenases Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.FTO levels affect RNA modification and the transcriptome Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption Identification of fat mass and obesity associated (FTO) protein expression in cardiomyocytes: regulation by leptin and its contribution to leptin-induced hypertrophy.Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5 Changes in gene expression associated with FTO overexpression in mice.Complex Relationship between Obesity and the Fat Mass and Obesity Locus Association of FTO polymorphisms with obesity and metabolic parameters in Han Chinese adolescents.Characterizing 5-methylcytosine in the mammalian epitranscriptome.Review of studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and its impact on lifestyle interventions.Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development.The role of the fat mass and obesity associated gene (FTO) in breast cancer risk.Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.Early hypothalamic FTO overexpression in response to maternal obesity--potential contribution to postweaning hyperphagia.Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight/obese Caucasian adults Effect of the FTO rs9930506 Polymorphism on the Main Comorbidities of the Cardiorenal Metabolic Syndrome in an Elderly Spanish Cohort.

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Overexpression of Fto leads to increased food intake and results in obesity

http://www.wikidata.org/entity/Q34479211

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Overexpression of Fto leads to increased food intake and results in obesity

@ast

Overexpression of Fto leads to increased food intake and results in obesity

@en

Overexpression of Fto leads to increased food intake and results in obesity

@nl

type

label

Overexpression of Fto leads to increased food intake and results in obesity

@ast

Overexpression of Fto leads to increased food intake and results in obesity

@en

Overexpression of Fto leads to increased food intake and results in obesity

@nl

prefLabel

Overexpression of Fto leads to increased food intake and results in obesity

@ast

Overexpression of Fto leads to increased food intake and results in obesity

@en

Overexpression of Fto leads to increased food intake and results in obesity

@nl

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Nature Genetics

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Overexpression of Fto leads to increased food intake and results in obesity

@en

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Chris Church

http://www.w3.org/2001/XMLSchema#string

Christophe Girard

http://www.w3.org/2001/XMLSchema#string

Frances M Ashcroft

http://www.w3.org/2001/XMLSchema#string

Lydia Teboul

http://www.w3.org/2001/XMLSchema#string

Sara Wells

http://www.w3.org/2001/XMLSchema#string

P2860

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

Crystal structure of the FTO protein reveals basis for its substrate specificity

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

Hypothalamic FTO is associated with the regulation of energy intake not feeding reward

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Genome-wide atlas of gene expression in the adult mouse brain

Inactivation of the Fto gene protects from obesity

The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain

Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

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1086-1092

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scholarly article

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10.1038/NG.713

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12

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42

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Patrick M. Nolan

Jens C Brüning

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2010-11-14T00:00:00Z

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47791814

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21076408

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3018646

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