Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma - Wikidata - awgldk - TriplyDB

Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma

Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma

http://www.wikidata.org/entity/Q34479414

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The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells SUMOylation of Blimp-1 promotes its proteasomal degradation Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma Unexpected functions of nuclear factor-κB during germinal center B-cell development: implications for lymphomagenesis The genetic landscape of diffuse large B-cell lymphoma NF-κB in cellular senescence and cancer treatment Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma.Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response.IκB kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor κB (NFκB) signaling.The generation of antibody-secreting plasma cells.MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.PRDM1 is a tumor suppressor gene in natural killer cell malignancies.Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications.Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20)Genetic lesions in diffuse large B-cell lymphomas Whole-exome analysis reveals novel somatic genomic alterations associated with outcome in immunochemotherapy-treated diffuse large B-cell lymphoma.Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma.The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7 Endothelial glucocorticoid receptor is required for protection against sepsis.MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies Low dose of lenalidmide and PI3K/mTOR inhibitor trigger synergistic cytoxicity in activated B cell-like subtype of diffuse large B cell lymphoma.Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease.Mechanisms linking obesity and cancer MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.Synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model.The downregulation of PRDM1/Blimp-1 is associated with aberrant expression of miR-223 in extranodal NK/T-cell lymphoma, nasal type.Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation.FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.

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Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma

http://www.wikidata.org/entity/Q34479414

description

2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Constitutive canonical NF-κB a ...... ke diffuse large cell lymphoma

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J.CCR.2010.11.024

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Constitutive canonical NF-κB a ...... ke diffuse large cell lymphoma

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Alexander Tarakhovsky

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Christine Unitt

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Dinis Pedro Calado

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Jane Seagal

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Jeffery Kutok

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Lakshmi Srinivasan

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Marc Schmidt-Supprian

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Scott Rodig

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Yoshiteru Sasaki

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P2860

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma

A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

Blimp1 is a critical determinant of the germ cell lineage in mice

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580-589

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10.1016/J.CCR.2010.11.024

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6

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Marc Schmidt-Supprian

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49681682

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21156282

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