Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. - Wikidata - awgldk - TriplyDB

Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.

Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.

http://www.wikidata.org/entity/Q34490491

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Role of MXD3 in proliferation of DAOY human medulloblastoma cells Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity MYC and the art of microRNA maintenance The role of MIZ-1 in MYC-dependent tumorigenesis HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma CDK6 as a key regulator of hematopoietic and leukemic stem cell activation Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron.Modulating the behaviors of mesenchymal stem cells via the combination of high-frequency vibratory stimulations and fibrous scaffolds.Coordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability.MYC and the control of apoptosis.EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression.BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma MYC cofactors: molecular switches controlling diverse biological outcomes.Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer.Akt and c-Myc induce stem-cell markers in mature primary p53⁻/⁻ astrocytes and render these cells gliomagenic in the brain of immunocompetent mice.Changes of T-lymphocyte subpopulation and differential expression pattern of the T-bet and GATA-3 genes in diffuse large B-cell lymphoma patients after chemotherapy The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis Apoptotic effects of two COX-2 inhibitors on breast adenocarcinoma cells through COX-2 independent pathway.MYC Is a Major Determinant of Mitotic Cell Fate.MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad.Two COX-2 inhibitors induce apoptosis in human erythroleukemia K562cells by modulating NF-κB and FHC pathways.A repressor protein, Mnt, is a novel negative regulator of vascular smooth muscle cell hypertrophy by angiotensin II and neointimal hyperplasia by arterial injury MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death.Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression.Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1.Application of conditionally replicating adenoviruses in tumor early diagnosis technology, gene-radiation therapy and chemotherapy.Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib.RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing.MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib.Activation of EIF4E by Aurora Kinase A Depicts a Novel Druggable Axis in Everolimus-Resistant Cancer Cells.Egr-1 promotes cell proliferation and invasion by increasing β-catenin expression in gastric cancer.FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling.The Myc-ARF-Egr1 pathway: unleashing the apoptotic power of c-Myc.p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia.EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy.Addicted to Myc--but why?

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P2860

Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.

http://www.wikidata.org/entity/Q34490491

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

@wuu

name

Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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type

label

Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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prefLabel

Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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Egr1 mediates p53-independent ...... ent transcriptional mechanism.

@en

Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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PNAS.1008848108

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Proceedings of the National Academy of Sciences of the United States of America

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Egr1 mediates p53-independent ...... ent transcriptional mechanism.

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P2093

David N Boone

http://www.w3.org/2001/XMLSchema#string

Stephen R Hann

http://www.w3.org/2001/XMLSchema#string

Ying Qi

http://www.w3.org/2001/XMLSchema#string

Zhaoliang Li

http://www.w3.org/2001/XMLSchema#string

P2860

Global mapping of c-Myc binding sites and target gene networks in human B cells

The INK4a/ARF network in tumour suppression

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.

Time-dependent c-Myc transactomes mapped by Array-based nuclear run-on reveal transcriptional modules in human B cells.

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

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scholarly article

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10.1073/PNAS.1008848108

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2

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108

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21187408

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3021028

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