Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization - Wikidata - awgldk - TriplyDB

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

http://www.wikidata.org/entity/Q29614701

about

"Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress p14ARF interacts with N-Myc and inhibits its transcriptional activity Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2 The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis.ZBP-89 promotes growth arrest through stabilization of p53 N-terminal polyubiquitination and degradation of the Arf tumor suppressor Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf Twist is a potential oncogene that inhibits apoptosis The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival p53-independent functions of the p19(ARF) tumor suppressor PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23 A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway A twist for survival and cancer progression c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL Epstein-Barr virus and Burkitt lymphoma Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism Immortalization of mouse myogenic cells can occur without loss of p16INK4a, p19ARF, or p53 and is accelerated by inactivation of Bax Developmental context determines latency of MYC-induced tumorigenesis p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

http://www.wikidata.org/entity/Q29614701

description

1998 nî lūn-bûn

@nan

1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

Myc signaling via the ARF tumo ...... apoptosis and immortalization

@ast

Myc signaling via the ARF tumo ...... apoptosis and immortalization

@en

type

label

Myc signaling via the ARF tumo ...... apoptosis and immortalization

@ast

Myc signaling via the ARF tumo ...... apoptosis and immortalization

@en

prefLabel

Myc signaling via the ARF tumo ...... apoptosis and immortalization

@ast

Myc signaling via the ARF tumo ...... apoptosis and immortalization

@en

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Genes & Development

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Myc signaling via the ARF tumo ...... apoptosis and immortalization

@en

P2093

C J Sherr

http://www.w3.org/2001/XMLSchema#string

C M Eischen

http://www.w3.org/2001/XMLSchema#string

D H Randle

http://www.w3.org/2001/XMLSchema#string

F Zindy

http://www.w3.org/2001/XMLSchema#string

J L Cleveland

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T Kamijo

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P2860

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Mdm2 promotes the rapid degradation of p53

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

Regulation of p53 stability by Mdm2

WAF1, a potential mediator of p53 tumor suppression

Oncogenic forms of p53 inhibit p53-regulated gene expression

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2424-2433

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894714

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10.1101/GAD.12.15.2424

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15

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12

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Martine F Roussel

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1998-08-01T00:00:00Z

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13590066

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9694806

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317045

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