Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.
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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasisHeterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a HydraActivators of G protein signaling exhibit broad functionality and define a distinct core signaling triadInvolvement of Girdin in the determination of cell polarity during cell migrationSrc homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifsMultimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.Integrated Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Quantitative Proteomic Analysis Identifies Galectin-1 as a Potential Biomarker for Predicting Sorafenib ResistFunctional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signalingCyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyDose- and time-dependent gene expression alterations in prostate and colon cancer cells after in vitro exposure to carbon ion and X-irradiation.Girdin regulates the migration and invasion of glioma cells via the PI3K-Akt signaling pathway.Integrins activate trimeric G proteins via the nonreceptor protein GIV/GirdinInterleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer.Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein ActivationGirdin expression in cervical carcinoma and its role in the malignant properties of HeLa cells.GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon CancerClinical significance of Girdin expression detected by immunohistochemistry in non-small cell lung cancer.Carbon ion irradiation of the human prostate cancer cell line PC3: a whole genome microarray study.Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism.The Gαi-GIV binding interface is a druggable protein-protein interactionPrognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer.Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer.Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization
P2860
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P2860
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@ast
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@en
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@nl
type
label
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@ast
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@en
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@nl
prefLabel
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@ast
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@en
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@nl
P2093
P2860
P356
P1433
P1476
Expression of GIV/Girdin, a me ...... ient survival in colon cancer.
@en
P2093
Barbara H Jung
Betty Cabrera
John M Carethers
Mikel Garcia-Marcos
Pradipta Ghosh
P2860
P304
P356
10.1096/FJ.10-167304
P407
P577
2010-10-25T00:00:00Z