Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
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Structural basis of Smoothened regulation by its extracellular domainsThe role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paperFunctional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome.Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.Sonic Hedgehog Signaling and Hippocampal Neuroplasticity.A new trick for an old lipid.Lipid metabolism fattens up hedgehog signaling.Inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase induces orofacial defects in zebrafish.Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.
P2860
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P2860
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
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2015 nî lūn-bûn
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2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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name
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@ast
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@en
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@nl
type
label
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@ast
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@en
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@nl
prefLabel
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@ast
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@en
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
@nl
P2093
P2860
P356
P1476
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome
@en
P2093
James I Macrae
John Jacob
Robert Blassberg
P2860
P304
P356
10.1093/HMG/DDV507
P577
2015-12-18T00:00:00Z