Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. - Wikidata - awgldk - TriplyDB

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

http://www.wikidata.org/entity/Q34506149

about

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death New Features about Tau Function and Dysfunction Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases Surface chemistry governs cellular tropism of nanoparticles in the brain.Glial contributions to neurodegeneration in tauopathies.Roles of tau protein in health and disease.Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.Non-Catalytic Roles of Presenilin Throughout Evolution.18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures.Efficacy of phosphodiesterase-4 inhibitors in juvenile Batten disease (CLN3).Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases.Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.Protein misfolding in neurodegenerative diseases: implications and strategies.Reversible phosphorylation of the 26S proteasome.A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.Tuning the proteasome to brighten the end of the journey.Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.CREB Signaling Is Involved in Rett Syndrome Pathogenesis Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.Concordance of Several Subcellular Interactions Initiates Alzheimer's Dementia: Their Reversal Requires Combination Treatment.The Proteasome and Oxidative Stress in Alzheimer's Disease.Rab7A regulates tau secretion.Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.The Logic of the 26S Proteasome.Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes.An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.K-BILDS: A Kinase Substrate Discovery Tool.Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy.Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.Tauopathies: Mechanisms and Therapeutic Strategies.Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases.Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.Impairment of protein degradation and proteasome function in hereditary neuropathies.Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study.

P2860

Q26738549-D3E2DFD1-7875-49D2-9FF8-EDC22D07A243 Q26750922-D81CC140-7A5B-41AA-B13C-9131CCFD1066 Q28073686-8300D178-3B82-415D-943E-6766E5FF8F1F Q30854434-7B1AD6F8-F3DC-44D1-A58E-1027A3CD7057 Q32173558-F5E8D86E-2FF4-44BD-8B46-FE2F139E3110 Q33559303-39281C86-7219-4D50-B179-AA9CD5B0818F Q33559307-4A0C9F19-5D0E-4B50-A8F9-2E749A1FDF99 Q36435295-6304CDDC-2794-46DF-A961-9F824F731244 Q36435405-0812A487-B9E1-4696-865B-E79C7750802A Q37053791-6116BEC3-B9E9-4AC7-8BD9-335D0241E26A Q37443865-278C20F9-8C3F-4740-AE28-5A872526AF2F Q37561375-DDC74AC4-6E94-4B3F-B7BC-5E85D1EEE8C6 Q37581070-19D3F44A-123B-486E-A25A-0930AE180B24 Q37598940-528783B2-041F-4C1D-8B2E-41F0108338FE Q37642955-F56D8D22-DF1E-48CB-BAFD-B62A4BAFBFA4 Q37697832-8B65DA95-4FE1-42C4-BEF4-28D63C59FAFA Q37712428-AC679A67-6C5B-4CC0-A0FB-BB1B09E3EDCE Q37739890-82116768-F6F2-455A-B779-5A3B79E06263 Q38559265-47C2C4AE-7DD6-449C-856D-D566C651CE94 Q38643963-AD5A4E3A-E036-4032-B7CF-86EDE846E434 Q38713212-A082169A-1D45-49A9-819F-6F6BCCB54976 Q38749683-5C44D857-9E6D-48FC-93CC-4D88E70B99B0 Q38829895-F3193EA6-9C74-4449-A1A0-75AFE3810D5C Q38843876-F0493293-AF6C-4485-B117-411EC963E6D7 Q38950095-074B29D0-B46B-45B7-A61B-9271D905F674 Q38998886-0FF9E382-E6E7-4A42-B046-CFE4856E32BE Q39318404-F4DFBD38-2E94-447F-8AEF-A192F3CAD920 Q41348866-97DE7F46-B026-4F63-87F3-6569B8BCEB67 Q41484754-07B88B5F-AB8F-49D7-9EC7-2E5F7A64F3D2 Q42279018-CB8DE7BE-6CE2-441C-9AC0-6BC30AC9CBAA Q42431910-A6E21198-144B-46AB-B996-B98A4D4B74F0 Q46916073-E251D253-A209-4C7E-8448-3D04780F31C2 Q47094629-22228E69-C1D7-4643-97FE-5FE84968B884 Q47111423-443C817A-0DB0-4903-8E2A-3906D24390FB Q47141859-9C6EE4A3-3A5B-4F9E-8AA5-6E0C47C09EBB Q47253592-D57A617F-27F4-41B0-878B-ECB6C1507F1E Q47301376-74C85175-A018-4F63-B65D-11F36A1B6030 Q47564614-D969F757-C536-443C-B086-EA014898D6C1 Q47596329-1E6647D7-31B4-4E04-A6B3-D74E7A48863C Q47654309-11872BF1-A531-4609-9F90-BB812C2879F8

P2860

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

http://www.wikidata.org/entity/Q34506149

description

2015 nî lūn-bûn

@nan

2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@ast

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@en

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@nl

type

label

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@ast

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@en

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@nl

prefLabel

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@ast

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@en

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@nl

P1433

Q34506149-B22E04DB-4593-41D3-ADB2-3502E79C3844

P1476

Q34506149-F54FB517-49EB-4676-8B02-907F5F53CA10

P2093

Q34506149-0D508998-E04D-4033-8D8D-DE4F6966C345

Q34506149-4B55E63E-74C3-480A-A588-6B984C503AC9

Q34506149-D1BC5B01-B442-4FCA-894D-7C492A87535D

Q34506149-DCC2C7FE-B498-4D51-9669-17BEA0D29CD3

Q34506149-F35952ED-05E2-4FE5-AF65-4CC8E4D3FED6

P2860

Q34506149-11A05132-BBB0-4EE3-941D-0579C61034A4

Q34506149-13B5F588-2A68-49D2-8177-DFE03C35CBF8

Q34506149-15005157-DE53-4947-9496-D7E289B244E8

Q34506149-19E7AD67-F676-4204-BD03-F913B39A9C1A

Q34506149-1DC69838-B572-4DB0-9C54-7683A91A67F8

Q34506149-1FE2CA33-73AD-4A33-A140-E17BD91B4469

Q34506149-25967E77-5F20-4B75-9298-011A7858D206

Q34506149-2753A80F-A931-421E-B28E-F00461D29EAD

Q34506149-2EC89CD3-4064-4E5D-8275-B9245042A07D

Q34506149-3830E189-A31D-4924-A3C4-A713E257D540

P2888

Q34506149-4FD9F8DD-F5FE-46B6-8D05-9F24B09964FA

P304

Q34506149-9204F62D-61B7-4164-9CC4-329847FCE69E

P31

Q34506149-093F52A7-A1EB-4840-A8C5-0805826C253D

P356

Q34506149-EEFCDBDA-CC66-49C1-AFA9-0353E7CDAC65

P407

Q34506149-78C487FA-BBF4-4C63-9554-7D9C1DC3C799

P433

Q34506149-D9B426D9-8766-47C6-8CE3-CBE06759C72A

P478

Q34506149-D236CA4B-E8E1-4B3F-97FC-6AED50AB5EA9

P50

Q34506149-6CA7B899-F96A-4B59-82F0-5399DE0E5112

Q34506149-796220AB-E4DB-43B6-AD2F-3099A0CAE9F6

P577

Q34506149-E1EE6743-E6A3-4B2C-97E5-72C46F38BE72

P5875

Q34506149-6F9E309D-75C3-4A33-8A88-D7C21180B017

P6179

Q34506149-B37B148A-B482-4C2F-9994-F9EEB652419B

P698

Q34506149-BC5615F7-D330-4FE6-A55A-648A326AE901

P932

Q34506149-E241BAFF-9247-43FB-A28D-B7E2296D116E

P356

P1433

Nature Medicine

P1476

Tau-driven 26S proteasome impa ...... activating cAMP-PKA signaling.

@en

P2093

Catherine L Clelland

http://www.w3.org/2001/XMLSchema#string

Natura Myeku

http://www.w3.org/2001/XMLSchema#string

Nikolay V Kukushkin

http://www.w3.org/2001/XMLSchema#string

Sheina Emrani

http://www.w3.org/2001/XMLSchema#string

Wai Haung Yu

http://www.w3.org/2001/XMLSchema#string

P2860

Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

Regulation of the autophagy protein LC3 by phosphorylation

The molecular and systems biology of memory

Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk.

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

Complete subunit architecture of the proteasome regulatory particle

Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation

Trans-synaptic spread of tau pathology in vivo

Recognition and processing of ubiquitin-protein conjugates by the proteasome

P2888

P304

46-53

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NM.4011

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

22

http://www.w3.org/2001/XMLSchema#string

P50

Alfred Goldberg

P577

2015-12-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

287806050

http://www.w3.org/2001/XMLSchema#string

P6179

1022708108

http://www.w3.org/2001/XMLSchema#string

P698

26692334

http://www.w3.org/2001/XMLSchema#string

P932

4787271

http://www.w3.org/2001/XMLSchema#string