Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.
about
Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcriptionHigh-content screening identifies a role for Na(+) channels in insulin productionRAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death.Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysEGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells.A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerEffects of insulin on human pancreatic cancer progression modeled in vitroInsulin stimulates primary beta-cell proliferation via Raf-1 kinase.Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip.Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.14-3-3 proteins are essential signalling hubs for beta cell survival.ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells.Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo.Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells.Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels.Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy.MAP kinase pathway is involved in IGF-1-stimulated proliferation of human retinal pigment epithelial cells (hRPE).Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells.The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice.The function of BTG3 in colorectal cancer cells and its possible signaling pathway.IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway.Reduced risk of apoptosis: mechanisms of stress responses.Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring.NAADP regulates human platelet function.
P2860
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P2860
Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@ast
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@en
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@nl
type
label
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@ast
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@en
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@nl
prefLabel
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@ast
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@en
Inhibition of Raf-1 alters mul ...... ancreatic beta-cell apoptosis.
@nl
P2860
P356
P1476
Inhibition of Raf-1 alters mul ...... pancreatic beta-cell apoptosis
@en
P2093
James D Johnson
P2860
P304
P356
10.1074/JBC.M703612200
P407
P577
2007-11-15T00:00:00Z