Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
about
X-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14 -Demethylase (CYP51)Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen HitDiverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptorA quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruziBenznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomicsRuthenium complex with benznidazole and nitric oxide as a new candidate for the treatment of chagas diseasePharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method.Effects of astaxanthin in mice acutely infected with Trypanosoma cruziScaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitorsNovel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity.In vitro and in vivo trypanocidal effects of the cyclopalladated compound 7a, a drug candidate for treatment of Chagas' disease.Current and developing therapeutic agents in the treatment of Chagas diseaseRisedronate metal complexes potentially active against Chagas disease.Clinical aspects of Chagas disease and implications for novel therapies.Dibenzylideneacetones Are Potent Trypanocidal Compounds That Affect the Trypanosoma cruzi Redox SystemThe Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process.Trypanosoma cruzi burden, genotypes, and clinical evaluation of Chilean patients with chronic Chagas cardiopathy.Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C on Trypanosoma cruziConcomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruziToxic Profile of Benznidazole in Patients with Chronic Chagas Disease: Risk Factors and Comparison of the Product from Two Different Manufacturers.Systematic Review and Meta-analysis of the Pharmacokinetics of Benznidazole in the Treatment of Chagas DiseaseNifurtimox reduces N-Myc expression and aerobic glycolysis in neuroblastoma.Antiparasitic Effect of Vitamin B12 on Trypanosoma cruzi.Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas DiseaseCurcumin Enhances the Anti-Trypanosoma cruzi Activity of Benznidazole-Based Chemotherapy in Acute Experimental Chagas Disease.ALDH2 mediates 5-nitrofuran activity in multiple species.Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay.Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease.Why does GM1 induce a potent beneficial response to experimental Chagas disease?Chagas' disease: an update on immune mechanisms and therapeutic strategiesExperimental chemotherapy against Trypanosoma cruzi infection using ruthenium nitric oxide donorsSide effects of benznidazole as treatment in chronic Chagas disease: fears and realities.Natural products and Chagas' disease: a review of plant compounds studied for activity against Trypanosoma cruzi.Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs - a mini review.Drug discovery for neglected diseases: molecular target-based and phenotypic approaches.Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi.
P2860
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P2860
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mode of action of natural and ...... ction with the mammalian host.
@ast
Mode of action of natural and ...... ction with the mammalian host.
@en
Mode of action of natural and ...... ction with the mammalian host.
@nl
type
label
Mode of action of natural and ...... ction with the mammalian host.
@ast
Mode of action of natural and ...... ction with the mammalian host.
@en
Mode of action of natural and ...... ction with the mammalian host.
@nl
prefLabel
Mode of action of natural and ...... ction with the mammalian host.
@ast
Mode of action of natural and ...... ction with the mammalian host.
@en
Mode of action of natural and ...... ction with the mammalian host.
@nl
P2093
P1476
Mode of action of natural and ...... action with the mammalian host
@en
P2093
Antonio Morello
Arturo Ferreira
Bruce K Cassels
Jorge Ferreira
Norbel Galanti
Patricio Iturriaga-Vásquez
P304
P356
10.1016/J.CBPA.2006.03.004
P5008
P577
2006-03-12T00:00:00Z