Microtubule-stabilizing agents based on designed laulimalide analogues. - Wikidata - awgldk - TriplyDB

Microtubule-stabilizing agents based on designed laulimalide analogues.

Microtubule-stabilizing agents based on designed laulimalide analogues.

http://www.wikidata.org/entity/Q34515802

about

The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A.Conformation-activity relationships of polyketide natural products.A reassignment of (-)-mycothiazole and the isolation of a related diol Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida.Function-oriented synthesis: biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy.Microtubule dynamics as a target in oncology.Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties.Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.A distinctive structural twist in the aminoimidazole alkaloids from a calcareous marine sponge: isolation and characterization of leucosolenamines A and B Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products.The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds.Analysis of the binding mode of laulimalide to microtubules: Establishing a laulimalide-tubulin pharmacophore.Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.

P2860

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P2860

Microtubule-stabilizing agents based on designed laulimalide analogues.

http://www.wikidata.org/entity/Q34515802

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Microtubule-stabilizing agents based on designed laulimalide analogues.

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Microtubule-stabilizing agents based on designed laulimalide analogues.

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Microtubule-stabilizing agents based on designed laulimalide analogues.

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type

label

Microtubule-stabilizing agents based on designed laulimalide analogues.

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Microtubule-stabilizing agents based on designed laulimalide analogues.

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Microtubule-stabilizing agents based on designed laulimalide analogues.

@nl

prefLabel

Microtubule-stabilizing agents based on designed laulimalide analogues.

@ast

Microtubule-stabilizing agents based on designed laulimalide analogues.

@en

Microtubule-stabilizing agents based on designed laulimalide analogues.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Microtubule-stabilizing agents based on designed laulimalide analogues.

@en

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Deborah A Randall-Hlubek

http://www.w3.org/2001/XMLSchema#string

Lei Zhang

http://www.w3.org/2001/XMLSchema#string

Paul A Wender

http://www.w3.org/2001/XMLSchema#string

Rachel M Leal

http://www.w3.org/2001/XMLSchema#string

Robert D Hubbard

http://www.w3.org/2001/XMLSchema#string

Sayee G Hegde

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Susan L Mooberry

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P2860

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics.

Synthetic approaches to the microtubule stabilizing agent (-)-laulimalide.

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.

Synthesis and biological evaluation of (-)-laulimalide analogues.

Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs.

Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization.

Macrocyclization via allyl transfer: total synthesis of laulimalide.

Total synthesis of microtubule-stabilizing agent (-)-laulimalide.

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8803-8808

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scholarly article

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10.1073/PNAS.0402759101

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23

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101

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8544436

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15161976

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423276

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