Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP)
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Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38deltaNFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress aloneHow do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?Intracellular water homeostasis and the mammalian cellular osmotic stress responsec-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBPHyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTPOsmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity.Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress.Macrophages in homeostatic immune function.Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors.Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.Determination of the NFAT5/TonEBP transcription factor in the human and ovine placentaRegulation of Mycobacterium tuberculosis-dependent HIV-1 transcription reveals a new role for NFAT5 in the toll-like receptor pathway.The Guanine Nucleotide Exchange Factor Brx: A Link between Osmotic Stress, Inflammation and Organ Physiology and PathophysiologyNFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney.cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein.Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicityATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.NF-AT5 is a critical regulator of inflammatory arthritisRac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5Placental TonEBP/NFAT5 osmolyte regulation in an ovine model of intrauterine growth restrictionMAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals.SRC family kinases in cell volume regulation.Dual effect of lithium on NFAT5 activity in kidney cells.DNA damage and osmotic regulation in the kidney.Amino acid metabolites that regulate G protein signaling during osmotic stress.Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscleInhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP)NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significanceHigh NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1.Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expressionTranscription factors in the pathogenesis of diabetic nephropathy.
P2860
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P2860
Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP)
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@ast
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@en
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@nl
type
label
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@ast
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@en
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@nl
prefLabel
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@ast
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@en
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@nl
P2093
P3181
P356
P1476
Fyn and p38 signaling are both ...... binding protein (OREBP/TonEBP)
@en
P2093
Amy K M Lam
Andras Kapus
Lingzhi Fan
Sookja K Chung
Stephen S M Chung
P304
46085-46092
P3181
P356
10.1074/JBC.M208138200
P407
P577
2002-09-30T00:00:00Z