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Present state and future perspectives of using pluripotent stem cells in toxicology research

Present state and future perspectives of using pluripotent stem cells in toxicology research

http://www.wikidata.org/entity/Q34520935

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Stem cell-derived liver cells for drug testing and disease modeling Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?Lead exposure disrupts global DNA methylation in human embryonic stem cells and alters their neuronal differentiation Effect of antibiotics against Mycoplasma sp. on human embryonic stem cells undifferentiated status, pluripotency, cell viability and growth Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells.Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling.A method for human teratogen detection by geometrically confined cell differentiation and migration From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.Regenerative medicine: transforming the drug discovery and development paradigm Pluripotent stem cells for the study of CNS development.Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery.The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk Precision toxicology based on single cell sequencing: an evolving trend in toxicological evaluations and mechanism exploration.Ionizing Radiation Impacts on Cardiac Differentiation of Mouse Embryonic Stem Cells.Wind of change challenges toxicological regulators.Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells.Key messages of recent publications in the field of toxicology.Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery.Bioreactor engineering of stem cell environments Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing.State of the art in stem cell research: human embryonic stem cells, induced pluripotent stem cells, and transdifferentiation.Cardiomyocyte culture - an update on the in vitro cardiovascular model and future challenges.Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative Diseases.Highlight report: New methods for quantification of bile canalicular dynamics.Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions.Quality metrics for stem cell-derived cardiac myocytes.Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling.In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Concise Review: Liver Regenerative Medicine: From Hepatocyte Transplantation to Bioartificial Livers and Bioengineered Grafts.Toxicity testing and drug screening using iPSC-derived hepatocytes, cardiomyocytes, and neural cells.Cytostatic Effect of Repeated Exposure to Simvastatin: A Mechanism for Chronic Myotoxicity Revealed by the Use of Mesodermal Progenitors Derived from Human Pluripotent Stem Cells.In vitro models of cranial neural crest development toward toxicity tests: frog, mouse, and human.Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes.B-cell receptor-associated protein 31 regulates human embryonic stem cell adhesion, stemness, and survival via control of epithelial cell adhesion molecule.Towards a New Paradigm in Nano-Genotoxicology: Facing Complexity of Nanomaterials' Cellular Interactions and Effects.Clinical potentials of human pluripotent stem cells.Surface bound amine functional group density influences embryonic stem cell maintenance.Transcriptomics in developmental toxicity testing.

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Present state and future perspectives of using pluripotent stem cells in toxicology research

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Low ethanol concentration alters CHRNA5 RNA levels during early human development

Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages

Embryonic stem cells and somatic cells differ in mutation frequency and type

Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions

Retinoic acid-induced neural differentiation of embryonal carcinoma cells

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells

Direct conversion of fibroblasts to functional neurons by defined factors

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Virus-free induction of pluripotency and subsequent excision of reprogramming factors

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