The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery. - Wikidata - awgldk - TriplyDB

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery.

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery.

http://www.wikidata.org/entity/Q37999093

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Biological detection by optical oxygen sensing.Stem cells and stem cell-derived tissues and their use in safety assessment.Toward predictive models for drug-induced liver injury in humans: are we there yet?Oncogenic protein interfaces: small molecules, big challenges.Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models.From Type I to Type II: Design, Synthesis, and Characterization of Potent Pyrazin-2-ones as DFG-Out Inhibitors of PDGFRβ.Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity.A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model.How can we discover safer drugs?

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The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery.

http://www.wikidata.org/entity/Q37999093

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The impact of assay technology ...... d attrition in drug discovery.

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The impact of assay technology ...... d attrition in drug discovery.

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The impact of assay technology ...... d attrition in drug discovery.

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The impact of assay technology ...... d attrition in drug discovery.

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The impact of assay technology ...... d attrition in drug discovery.

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The impact of assay technology ...... d attrition in drug discovery.

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17460441.2012.651122

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Expert Opinion on Drug Discovery

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The impact of assay technology ...... d attrition in drug discovery.

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Craig E Thomas

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Yvonne Will

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Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches.

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.

Current and future applications of toxicogenomics: Results summary of a survey from the HESI Genomics State of Science Subcommittee

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109-122

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10.1517/17460441.2012.651122

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