Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.
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HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycleEvolution of the arginase fold and functional diversityHDAC8 substrates: Histones and beyondRegulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigeneticsStructural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors † , ‡Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function,The Structure- and Metal-dependent Activity of Escherichia coli PgaB Provides Insight into the Partial De-N-acetylation of Poly- -1,6-N-acetyl-D-glucosamineStructural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone DeacetylasesModulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesActivation and inhibition of histone deacetylase 8 by monovalent cations.Inhibition and mechanism of HDAC8 revisited.Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions.The redox basis of epigenetic modifications: from mechanisms to functional consequences.Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.A miniaturized readout strategy for endogenous histone deacetylase activity.An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity.On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysisTargeting Histone Deacetylases in Diseases: Where Are We?KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas.Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase.Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.General Base-General Acid Catalysis in Human Histone Deacetylase 8.Insights from comprehensive multiple receptor docking to HDAC8.Synthesis and evaluation of N⁸-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolaseChemical mechanisms of histone lysine and arginine modificationsLoop interactions and dynamics tune the enzymatic activity of the human histone deacetylase 8.New patented histone deacetylase inhibitors.Toward isozyme-selective inhibitors of histone deacetylase as therapeutic agents for the treatment of cancer.Purification of metal-dependent lysine deacetylases with consistently high activity.Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates.Metal-dependent Deacetylases: Cancer and Epigenetic RegulatorsInterrogating Substrate Selectivity and Composition of Endogenous Histone Deacetylase Complexes with Chemical Probes.Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.Curcumin and hydroxamate-derivative (PCI-34058) interfere with histone deacetylase I catalytic core Asp-His charge relay system: atomistic simulation studies.Chemical and structural biology of protein lysine deacetylasesThe Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase.KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay.Structural and thermodynamic characterization of metal binding in Vps29 from Entamoeba histolytica: Implication in retromer function.
P2860
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P2860
Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Catalytic activity and inhibit ...... of the active site metal ion.
@ast
Catalytic activity and inhibit ...... of the active site metal ion.
@en
Catalytic activity and inhibit ...... of the active site metal ion.
@nl
type
label
Catalytic activity and inhibit ...... of the active site metal ion.
@ast
Catalytic activity and inhibit ...... of the active site metal ion.
@en
Catalytic activity and inhibit ...... of the active site metal ion.
@nl
prefLabel
Catalytic activity and inhibit ...... of the active site metal ion.
@ast
Catalytic activity and inhibit ...... of the active site metal ion.
@en
Catalytic activity and inhibit ...... of the active site metal ion.
@nl
P2093
P356
P1433
P1476
Catalytic activity and inhibit ...... of the active site metal ion.
@en
P2093
Carol A Fierke
Samuel G Gattis
Stephanie L Gantt
P304
P356
10.1021/BI060212U
P407
P577
2006-05-01T00:00:00Z