Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
about
The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer TherapeuticsGranulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinomaMonoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors.Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3.Role of GRP78 in promoting therapeutic-resistant breast cancerActivated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein.Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potentialmTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines.Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78.ROS-independent Nrf2 activation in prostate cancerSubstrain-specific differences in bone parameters, alpha-2-macroglobulin circulating levels, and osteonecrosis incidence in a rat model.Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells.GRP78 and α2-macroglobulin are new promising targets for metastatic castrate-resistant prostate cancer treatment.
P2860
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P2860
Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@ast
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@en
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@nl
type
label
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@ast
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@en
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@nl
prefLabel
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@ast
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@en
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@nl
P2860
P1433
P1476
Receptor-recognized α₂-macrogl ...... ling in prostate cancer cells.
@en
P2093
Salvatore V Pizzo
Uma K Misra
P2860
P304
P356
10.1371/JOURNAL.PONE.0051735
P407
P577
2012-12-14T00:00:00Z