Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis. - Wikidata - awgldk - TriplyDB

Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.

Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.

http://www.wikidata.org/entity/Q34118737

about

Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics Membrane-associated GRP78 helps subgroup J avian leucosis virus enter cells Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a 64Cu-Labeled Monoclonal Antibody, MAb159.Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface.Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors.Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma.Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3.The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis.Role of GRP78 in promoting therapeutic-resistant breast cancer Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein.Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.New insights into the unfolded protein response in stem cells.Prostate cancer and the unfolded protein response.GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression.Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.Endoplasmic reticulum proteins quality control and the unfolded protein response: the regulative mechanism of organisms against stress injuries.Intracellular antigens as targets for antibody based immunotherapy of malignant diseases.Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78.Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma.Targeting the unfolded protein response in cancer.Glucose-Regulated Protein 78-Induced Myeloid Antigen-Presenting Cells Maintained Tolerogenic Signature upon LPS Stimulation.The meta and bioinformatics analysis of GRP78 expression in gastric cancer.GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.Targeting protein quality control pathways in breast cancer.Lectin BS-I inhibits cell migration and invasion via AKT/GSK-3β/β-catenin pathway in hepatocellular carcinoma.The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone.

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P2860

Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.

http://www.wikidata.org/entity/Q34118737

description

2013 nî lūn-bûn

@nan

2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

@zh-hk

2013年論文

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2013年論文

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2013年论文

@wuu

name

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@ast

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@en

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@nl

type

label

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@ast

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@en

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@nl

prefLabel

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@ast

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@en

Monoclonal antibody against ce ...... tumor growth, and metastasis.

@nl

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1078-0432.CCR-13-1106

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Clinical Cancer Research

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Monoclonal antibody against ce ...... , tumor growth, and metastasis

@en

P2093

Dan Li

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Dezheng Dong

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Genyuan Zhu

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Parkash S Gill

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Peter S Conti

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Ren Liu

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Satyajit K Mitra

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Shiuan Wey

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Shuanglong Liu

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Stan Louie

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P2860

GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth.

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.

Mouse prostate cancer cell lines established from primary and postcastration recurrent tumors.

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death

Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model

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24

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