Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
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Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cellsHow Much Binding Affinity Can be Gained by Filling a Cavity?3-(5-Oxo-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzonitrileChemical composition of Nigella sativa Linn: Part 2 Recent advancesAllosteric modulation of metabotropic glutamate receptors.Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsA chemoselective Ugi-type reaction in water using TMSCN as a functional isonitrile equivalent: generation of heteroaromatic molecular diversity.Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningGlutamatergic targets for enhancing extinction learning in drug addictionDesign and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonistsHydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazolesAllosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.A Robust Protocol for Pd(II)-catalyzed C-3 Arylation of (1H) Indazoles and Pyrazoles: Total Synthesis of Nigellidine HydrobromideActivation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.Allosteric modulators for mGlu receptors.Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Approaches towards the synthesis of 5-aminopyrazoles.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Metabotropic glutamate receptor 5 as a potential therapeutic target in Huntington's disease.Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTSNovel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury.Ligand-Promoted C(sp(3) )-H Olefination en Route to Multi-functionalized Pyrazoles.Azolyacetones as precursors to indoles and naphthofurans facilitated by microwave irradiation with simultaneous cooling.Effects of the Positive Allosteric Modulator of Metabotropic Glutamate Receptor 5, VU-29, on Impairment of Novel Object Recognition Induced by Acute Ethanol and Ethanol Withdrawal in Rats.Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism.Selective synthesis of 4-(sulfonyl)-methyl-1H-pyrazoles and (E)-4,5-dihydro-1H-pyrazoles from N-allenic sulfonylhydrazones.An efficient copper-catalyzed formation of highly substituted pyrazoles using molecular oxygen as the oxidant
P2860
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P2860
Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
description
2006 nî lūn-bûn
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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@ast
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@en
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@nl
type
label
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@ast
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@en
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@nl
prefLabel
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@ast
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@en
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@nl
P2093
P356
P1476
Substituent effects of N-(1,3- ...... or in rat cortical astrocytes.
@en
P2093
David Alagille
Gilles D Tamagnan
Kamondanai Hemstapat
Ronald M Baldwin
Samir Saleh
Tomas de Paulis
Yelin Chen
Yongqin Zhang
P304
P356
10.1021/JM051252J
P407
P577
2006-06-01T00:00:00Z