Increased cell-to-cell variation in gene expression in ageing mouse heart.
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Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with ageSIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during agingNature, nurture, or chance: stochastic gene expression and its consequencesTwo faces of p53: aging and tumor suppressionCellular Senescence as the Causal Nexus of AgingUsing measures of single-cell physiology and physiological state to understand organismic agingLongitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative diseaseOn the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespanThe hallmarks of agingSingle-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated allelesCirculating nucleic acids: a new class of physiological mobile genetic elementsQuantifying intrinsic and extrinsic variability in stochastic gene expression modelsPuma is required for p53-induced depletion of adult stem cellsHighly parallel genome-wide expression analysis of single mammalian cellsThe spatial association of gene expression evolves from synchrony to asynchrony and stochasticity with ageTrends in modeling Biomedical Complex SystemsAre aberrant phase transitions a driver of cellular aging?Stochastic profiling of transcriptional regulatory heterogeneities in tissues, tumors and cultured cellsCo-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform.Identifying single-cell molecular programs by stochastic profiling.H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cellsA structured population modeling framework for quantifying and predicting gene expression noise in flow cytometry data.The asymmetry of telomere replication contributes to replicative senescence heterogeneity.Conceptual and data-based investigation of genetic influences and brain asymmetry: a twin study of multiple structural phenotypesPathway-based factor analysis of gene expression data produces highly heritable phenotypes that associate with age.A model selection approach to discover age-dependent gene expression patterns using quantile regression models.High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged miceMitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence.Switch-like genes populate cell communication pathways and are enriched for extracellular proteinsCell-to-cell stochastic variation in gene expression is a complex genetic trait.Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males.An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells.Aging mice show a decreasing correlation of gene expression within genetic modulesThe central role of chromatin maintenance in aging.Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.The biology of aging: 1985-2010 and beyond.Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity
P2860
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P2860
Increased cell-to-cell variation in gene expression in ageing mouse heart.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@ast
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@en
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@nl
type
label
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@ast
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@en
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@nl
prefLabel
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@ast
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@en
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@nl
P2093
P356
P1433
P1476
Increased cell-to-cell variation in gene expression in ageing mouse heart.
@en
P2093
Ashley D Denny
Brad H Pollock
Christoph A Klein
Claudia H Hartmann
Gary B Chisholm
Karl A Rodriguez
Martijn E T Dollé
R Brent Calder
Rita A Busuttil
P2888
P304
P356
10.1038/NATURE04844
P407
P577
2006-06-01T00:00:00Z
P5875
P6179
1008393996