Rational design of combination enzyme therapy for celiac sprue.
about
A food-grade enzyme preparation with modest gluten detoxification propertiesIn vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tractProtein engineering of improved prolyl endopeptidases for celiac sprue therapyEngineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions.Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaquesDiscovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavityParallels between pathogens and gluten peptides in celiac sprueToward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide.Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells.Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract.Novel therapies for coeliac diseaseThe cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity.Celiac disease: a disorder emerging from antiquity, its evolving classification and risk, and potential new treatment paradigms.Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.Celiac disease: pathogenesis of a model immunogenetic disease.Noninflammatory gluten peptide analogs as biomarkers for celiac sprue.Rapid isolation of gluten-digesting bacteria from human stool and saliva by using gliadin-containing plates.In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options.Future treatment strategies for celiac disease.Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes.Recent advances in the development of new treatments for celiac disease.Advances in the treatment of coeliac disease: an immunopathogenic perspective.Celiac disease: the search for adjunctive or alternative therapies.Current status of drugs in development for celiac disease.Emerging drugs for coeliac disease.Emerging drugs for celiac disease.Celiac disease 2015 update: new therapies.Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients.Physiopathology and Management of Gluten-Induced Celiac Disease.Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides.New and developing therapies for celiac disease.Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease.Computational design of an α-gliadin peptidaseEffect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac disease.Oral proteases: a new approach to managing coeliac disease.Oral enzyme therapy for celiac sprue.Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2.Safety, tolerability, and activity of ALV003: results from two phase 1 single, escalating-dose clinical trials.Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac disease.Identification and characterization of intestinal lactobacilli strains capable of degrading immunotoxic peptides present in gluten.
P2860
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P2860
Rational design of combination enzyme therapy for celiac sprue.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Rational design of combination enzyme therapy for celiac sprue.
@ast
Rational design of combination enzyme therapy for celiac sprue.
@en
Rational design of combination enzyme therapy for celiac sprue.
@nl
type
label
Rational design of combination enzyme therapy for celiac sprue.
@ast
Rational design of combination enzyme therapy for celiac sprue.
@en
Rational design of combination enzyme therapy for celiac sprue.
@nl
prefLabel
Rational design of combination enzyme therapy for celiac sprue.
@ast
Rational design of combination enzyme therapy for celiac sprue.
@en
Rational design of combination enzyme therapy for celiac sprue.
@nl
P2093
P50
P1476
Rational design of combination enzyme therapy for celiac sprue
@en
P2093
Alexandre Johannsen
Chaitan Khosla
Gary M Gray
Jennifer Ehren
Jonathan Gass
Matthew Siegel
Michael T Bethune
P304
P356
10.1016/J.CHEMBIOL.2006.04.009
P577
2006-06-01T00:00:00Z