Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs
about
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexesPolymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphismsHuman exonuclease I is required for 5' and 3' mismatch repairhMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.DNA polymerase delta is required for human mismatch repair in vitroEvidence for involvement of HMGB1 protein in human DNA mismatch repairThe interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female miceInteraction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complexDNA mismatch repair: molecular mechanism, cancer, and ageingRecognition and binding of mismatch repair proteins at an oncogenic hot spotPCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cellsThe Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human CancerStructure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase.Functional residues on the surface of the N-terminal domain of yeast Pms1Structure of the endonuclease domain of MutL: unlicensed to cut.Distinct Structural Alterations in Proliferating Cell Nuclear Antigen Block DNA Mismatch RepairThe Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs.The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerIdentification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNANuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsInactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterilityDNA mismatch repair and mutation avoidance pathwaysExonuclease 1-dependent and independent mismatch repairCharacterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesDifferent mutator phenotypes in Mlh1- versus Pms2-deficient micePartial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein AATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairIsolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaMultiple functions of MutS- and MutL-related heterocomplexesAltered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA)Meiosis genes in Daphnia pulex and the role of parthenogenesis in genome evolution.
P2860
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P2860
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Restoration of mismatch repair ...... rodimer of human MutL homologs
@ast
Restoration of mismatch repair ...... rodimer of human MutL homologs
@en
Restoration of mismatch repair ...... rodimer of human MutL homologs
@nl
type
label
Restoration of mismatch repair ...... rodimer of human MutL homologs
@ast
Restoration of mismatch repair ...... rodimer of human MutL homologs
@en
Restoration of mismatch repair ...... rodimer of human MutL homologs
@nl
prefLabel
Restoration of mismatch repair ...... rodimer of human MutL homologs
@ast
Restoration of mismatch repair ...... rodimer of human MutL homologs
@en
Restoration of mismatch repair ...... rodimer of human MutL homologs
@nl
P2860
P356
P1476
Restoration of mismatch repair ...... rodimer of human MutL homologs
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.6.1950
P407
P50
P577
1995-03-01T00:00:00Z