Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility - Wikidata - awgldk - TriplyDB

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

http://www.wikidata.org/entity/Q28182219

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Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems Okazaki fragment maturation: nucleases take centre stage DNA mismatch repair: molecular mechanism, cancer, and ageing Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer Nucleases in homologous recombination as targets for cancer therapy Single-molecule views of MutS on mismatched DNA.Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases Causal link between microsatellite instability and hMRE11 dysfunction in human cancers Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family Impact of DNA mismatch repair system alterations on human fertility and related treatments New insights into the mechanism of DNA mismatch repair CSB-PGBD3 Mutations Cause Premature Ovarian Failure Exonuclease 1-dependent and independent mismatch repair Mechanisms and functions of DNA mismatch repair DNA mismatch repair in eukaryotes and bacteria Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice Breast tumors with elevated expression of 1q candidate genes confer poor clinical outcome and sensitivity to Ras/PI3K inhibition Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites Human mismatch repair: reconstitution of a nick-directed bidirectional reaction.Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins.Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.Genome-wide identification of CBX2 targets: insights in the human sex development network.CtIP-mediated resection is essential for viability and can operate independently of BRCA1.Eukaryotic Mismatch Repair in Relation to DNA Replication Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.Hydrolytic function of Exo1 in mammalian mismatch repair.An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.Repair of endogenous DNA base lesions modulate lifespan in mice PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.

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Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

http://www.wikidata.org/entity/Q28182219

description

2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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Inactivation of Exonuclease 1 ...... and male and female sterility

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Inactivation of Exonuclease 1 ...... and male and female sterility

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Inactivation of Exonuclease 1 ...... and male and female sterility

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type

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Inactivation of Exonuclease 1 ...... and male and female sterility

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Inactivation of Exonuclease 1 ...... and male and female sterility

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Inactivation of Exonuclease 1 ...... and male and female sterility

@nl

prefLabel

Inactivation of Exonuclease 1 ...... and male and female sterility

@ast

Inactivation of Exonuclease 1 ...... and male and female sterility

@en

Inactivation of Exonuclease 1 ...... and male and female sterility

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Genes & Development

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Inactivation of Exonuclease 1 ...... and male and female sterility

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Alan B Clark

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Burkhard Kneitz

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Dan J Mazur

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Edmund Wong

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Guohze Yang

http://www.w3.org/2001/XMLSchema#string

Harry Hou

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Kaichun Wei

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Michael F Kane

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Nadine K Kolas

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Paula E Cohen

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P2860

Human exonuclease I interacts with the mismatch repair protein hMSH2

The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

The interaction of DNA mismatch repair proteins with human exonuclease I

Human exonuclease I is required for 5' and 3' mismatch repair

Molecular interactions of human Exo1 with DNA

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.

Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.

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10.1101/GAD.1060603

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12629043

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