TCF7L2 is a master regulator of insulin production and processing. - Wikidata - awgldk - TriplyDB

TCF7L2 is a master regulator of insulin production and processing.

TCF7L2 is a master regulator of insulin production and processing.

http://www.wikidata.org/entity/Q34555421

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Pharmacogenetic studies update in type 2 diabetes mellitus Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic R Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment.Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci Association of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.Genetics of type 2 diabetes-pitfalls and possibilities.Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study.TCF/Lef regulates the Gsx ParaHox gene in central nervous system development in chordates Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis.Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico.The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.Type 2 Diabetes Risk Allele Loci in the Qatari Population.Interaction of Wnt pathway related variants with type 2 diabetes in a Chinese Han population.Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass.TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.Epigenetic modifications and long noncoding RNAs influence pancreas development and function.Computational analyses of type 2 diabetes-associated loci identified by genome-wide association studies.miRNAs: early prognostic biomarkers for Type 2 diabetes mellitus?Genetic markers predicting sulphonylurea treatment outcomes in type 2 diabetes patients: current evidence and challenges for clinical implementation.Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk.Pharmacogenetic aspects of the treatment of Type 2 diabetes with the incretin effect enhancers.Transcriptome analysis in blood cells from children reveals potential early biomarkers of metabolic alterations.Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence.Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.Vitamin B12 supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits.Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes.

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P2860

TCF7L2 is a master regulator of insulin production and processing.

http://www.wikidata.org/entity/Q34555421

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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TCF7L2 is a master regulator of insulin production and processing.

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Human Molecular Genetics

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TCF7L2 is a master regulator of insulin production and processing.

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Claes Wollheim

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Emilia Ottosson-Laakso

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Erik Renström

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Hedvig Bennet

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Jing Su

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Kathleen Bailey

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Leif Groop

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Liliya Shcherbina

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Marcelo Nobrega

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Nikolay Oskolkov

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P2860

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Fast gapped-read alignment with Bowtie 2

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

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6419-6431

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10.1093/HMG/DDU359

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24

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23

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