An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats
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Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese ratsSoluble epoxide hydrolase as a therapeutic target for cardiovascular diseasesDiscovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indicationsCyclooxygenase- and cytochrome P450-derived eicosanoids in strokeSoluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidneySoluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitationEpoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor responsePharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammationInsulin resistance and endothelial dysfunction: Are epoxyeicosatrienoic acids the link?Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single AgentInhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammationThe 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic painCytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammationSoluble epoxide hydrolase inhibition modulates vascular remodelingSoluble epoxide hydrolase in atherosclerosisCytochrome P450 eicosanoids and cerebral vascular functionEpoxides and soluble epoxide hydrolase in cardiovascular physiologyPharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogsDevelopment of a high-throughput screen for soluble epoxide hydrolase inhibitionEffect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion.Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal diseaseHypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition.Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes.Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats.The effects of hypertension on the cerebral circulation.Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures.Soluble epoxide hydrolase gene deletion improves blood flow and reduces infarct size after cerebral ischemia in reproductively senescent female mice.Inhibition of soluble epoxide hydrolase reduces food intake and increases metabolic rate in obese mice.Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.High salt diet modulates vascular response in A2AAR (+/+) and A 2AAR (-/-) mice: role of sEH, PPARγ, and K ATP channels.Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone ratsPharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeysSoluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex.Genetic susceptibility to inflammatory injury and various adverse outcomesSubstituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapieSoluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke.The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture.
P2860
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P2860
An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@ast
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@en
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@nl
type
label
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@ast
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@en
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@nl
prefLabel
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@ast
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@en
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@nl
P2093
P2860
P1476
An epoxide hydrolase inhibitor ...... pontaneously hypertensive rats
@en
P2093
Anne M Dorrance
Bruce D Hammock
David M Pollock
John D Imig
John W Newman
Nicole Rupp
P2860
P304
P356
10.1097/01.FJC.0000189600.74157.6D
P577
2005-12-01T00:00:00Z