Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity
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Fine-tuning translation kinetics selection as the driving force of codon usage bias in the hepatitis A virus capsidThe distribution of synonymous codon choice in the translation initiation region of dengue virusAnalysis of codon usage and nucleotide composition bias in poliovirusesVirus attenuation by genome-scale changes in codon pair biasPutting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesisSynthetic viruses: a new opportunity to understand and prevent viral diseaseExploiting tRNAs to Boost VirulenceDevelopment of next-generation respiratory virus vaccines through targeted modifications to viral immunomodulatory genesRescue of recent virulent and avirulent field strains of bluetongue virus by reverse geneticsUtilisation of ISA Reverse Genetics and Large-Scale Random Codon Re-Encoding to Produce Attenuated Strains of Tick-Borne Encephalitis Virus within DaysVaccines: the Fourth CenturyCRPV genomes with synonymous codon optimizations in the CRPV E7 gene show phenotypic differences in growth and altered immunity upon E7 vaccinationDirect interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesisFurther studies on the role of the residue 890 cysteine to tyrosine mutation in the M70 primase ORF of the temperature-sensitive mutant (tsm5) of murine cytomegalovirus.Live attenuated influenza virus vaccines by computer-aided rational design.Pandemic influenza A virus codon usage revisited: biases, adaptation and implications for vaccine strain developmentRandom codon re-encoding induces stable reduction of replicative fitness of Chikungunya virus in primate and mosquito cellsThe systemic imprint of growth and its uses in ecological (meta)genomics.RCDI/eRCDI: a web-server to estimate codon usage deoptimization.Mutational and fitness landscapes of an RNA virus revealed through population sequencingRNA virus reverse genetics and vaccine design.Codon usage bias: causative factors, quantification methods and genome-wide patterns: with emphasis on insect genomes.Rationalizing the development of live attenuated virus vaccinesRefining the balance of attenuation and immunogenicity of respiratory syncytial virus by targeted codon deoptimization of virulence genesBicluster pattern of codon context usages between flavivirus and vector mosquito Aedes aegypti: relevance to infection and transcriptional response of mosquito genes.Effect of formaldehyde inactivation on poliovirusIdentification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated designPicornavirus morphogenesis.Large-scale de novo DNA synthesis: technologies and applications.Identification and manipulation of the molecular determinants influencing poliovirus recombination.Polypyrimidine tract binding protein-1 (PTB1) is a determinant of the tissue and host tropism of a human rhinovirus/poliovirus chimera PV1(RIPO).Infectious Bronchitis Virus as a Vector for the Expression of Heterologous Genes.A host-specific, temperature-sensitive translation defect determines the attenuation phenotype of a human rhinovirus/poliovirus chimera, PV1(RIPO).Genome-wide analysis of codon usage and influencing factors in chikungunya viruses.Attenuation of tick-borne encephalitis virus using large-scale random codon re-encodingComputationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector.FRESCo: finding regions of excess synonymous constraint in diverse virusesLarge-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference.Development of live-attenuated arenavirus vaccines based on codon deoptimizationGenomic analysis of codon usage shows influence of mutation pressure, natural selection, and host features on Marburg virus evolution.
P2860
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P2860
Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Reduction of the rate of polio ...... lowering specific infectivity
@ast
Reduction of the rate of polio ...... lowering specific infectivity
@en
Reduction of the rate of polio ...... lowering specific infectivity
@nl
type
label
Reduction of the rate of polio ...... lowering specific infectivity
@ast
Reduction of the rate of polio ...... lowering specific infectivity
@en
Reduction of the rate of polio ...... lowering specific infectivity
@nl
prefLabel
Reduction of the rate of polio ...... lowering specific infectivity
@ast
Reduction of the rate of polio ...... lowering specific infectivity
@en
Reduction of the rate of polio ...... lowering specific infectivity
@nl
P2093
P2860
P356
P1433
P1476
Reduction of the rate of polio ...... lowering specific infectivity
@en
P2093
Dimitris Papamichail
J Robert Coleman
Steffen Mueller
Steven Skiena
P2860
P304
P356
10.1128/JVI.00738-06
P407
P577
2006-10-01T00:00:00Z