Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.
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Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiologyThe A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channelPeripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors.Adenosine A3 receptor activation attenuates lung ischemia-reperfusion injury.Activation of the A(3) adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils.Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts.Cardiac purinergic signalling in health and diseaseAdenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricleActivation of the A(3) adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils.Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling.Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptorAdenosine A(3) receptors regulate heart rate, motor activity and body temperature.Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs).Adenosine receptor-mediated cardioprotection: are all 4 subtypes required or redundant?Evidence that the acute phase of ischemic preconditioning does not require signaling by the A 2B adenosine receptorInternational Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an updateImpairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury.Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemiaAn adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway.Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanismA3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats.Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning.Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor.MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore PathwayAnti-ischemic effects of multivalent dendrimeric A₃ adenosine receptor agonists in cultured cardiomyocytes and in the isolated rat heart.Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.Controlling murine and rat chronic pain through A3 adenosine receptor activationStructure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver.Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic MiceCharacterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic CardiomyopathyApolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia.Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors.Adenosine receptor subtypes and the heart failure phenotype: translating lessons from mice to man.Adenosine receptor targeting in health and disease.Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.
P2860
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P2860
Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
Cl-IB-MECA [2-chloro-N6-
@nl
Cl-IB-MECA [2-chloro-N6-(3-iod ...... ing the A3 adenosine receptor.
@ast
Cl-IB-MECA [2-chloro-N6-(3-iod ...... ing the A3 adenosine receptor.
@en
type
label
Cl-IB-MECA [2-chloro-N6-
@nl
Cl-IB-MECA [2-chloro-N6-(3-iod ...... ing the A3 adenosine receptor.
@ast
Cl-IB-MECA [2-chloro-N6-(3-iod ...... ing the A3 adenosine receptor.
@en
prefLabel
Cl-IB-MECA [2-chloro-N6-
@nl
Cl-IB-MECA [2-chloro-N6-(3-iod ...... ing the A3 adenosine receptor.
@ast
Cl-IB-MECA [2-chloro-N6-(3-iod ...... ing the A3 adenosine receptor.
@en
P2093
P356
P1476
Cl-IB-MECA [2-chloro-N6-(3-iod ...... ing the A3 adenosine receptor.
@en
P2093
Garrett J Gross
Jason N Peart
John A Auchampach
Laura M Kreckler
Marlene A Jacobson
Tina C Wan
Zhi-Dong Ge
P304
P356
10.1124/JPET.106.111351
P407
P577
2006-09-19T00:00:00Z