Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide
about
RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteriaStructural insight into nascent polypeptide chain-mediated translational stalling.Macrolide antibiotics allosterically predispose the ribosome for translation arrest.Genetic identification of nascent peptides that induce ribosome stalling.Ribosomes in a stacked array: elucidation of the step in translation elongation at which they are stalled during S-adenosyl-L-methionine-induced translation arrest of CGS1 mRNA.Large facilities and the evolving ribosome, the cellular machine for genetic-code translationThe arginine attenuator peptide interferes with the ribosome peptidyl transferase center.Isolation of translating ribosomes containing peptidyl-tRNAs for functional and structural analysesA new suite of tnaA mutants suggests that Escherichia coli tryptophanase is regulated by intracellular sequestration and by occlusion of its active siteRecognition of the regulatory nascent chain TnaC by the ribosomeRibosome recycling factor and release factor 3 action promotes TnaC-peptidyl-tRNA Dropoff and relieves ribosome stalling during tryptophan induction of tna operon expression in Escherichia coliRibosomal features essential for tna operon induction: tryptophan binding at the peptidyl transferase center.A case for "StopGo": reprogramming translation to augment codon meaning of GGN by promoting unconventional termination (Stop) after addition of glycine and then allowing continued translation (Go)Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function.Arginine changes the conformation of the arginine attenuator peptide relative to the ribosome tunnelConserved residues Asp16 and Pro24 of TnaC-tRNAPro participate in tryptophan induction of Tna operon expression.uORFs with unusual translational start codons autoregulate expression of eukaryotic ornithine decarboxylase homologsModulating the activity of the peptidyl transferase center of the ribosome.Regional discrimination and propagation of local rearrangements along the ribosomal exit tunnel.The ribosome: a metabolite-responsive transcription regulator.23S rRNA nucleotides in the peptidyl transferase center are essential for tryptophanase operon inductionTryptophan inhibits Proteus vulgaris TnaC leader peptide elongation, activating tna operon expression.Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.Divergent stalling sequences sense and control cellular physiology.The ribosome as a hub for protein quality control.Fidelity of cotranslational protein targeting by the signal recognition particle.Identification of Arabidopsis thaliana upstream open reading frames encoding peptide sequences that cause ribosomal arrest.S-adenosyl-L-methionine induces compaction of nascent peptide chain inside the ribosomal exit tunnel upon translation arrest in the Arabidopsis CGS1 gene.Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnelSignal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel.Modulation of the rate of peptidyl transfer on the ribosome by the nature of substrates.Effect of Nascent Peptide Steric Bulk on Elongation Kinetics in the Ribosome Exit Tunnel.Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.
P2860
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P2860
Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide
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2006 nî lūn-bûn
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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2006 թվականի փետրվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@ast
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@en
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@nl
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label
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@ast
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@en
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@nl
prefLabel
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@ast
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@en
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@nl
P2093
P2860
P356
P1476
Changes produced by bound tryp ...... TnaC, a nascent leader peptide
@en
P2093
Charles Yanofsky
Luis Rogelio Cruz-Vera
P2860
P304
P356
10.1073/PNAS.0600082103
P407
P577
2006-02-27T00:00:00Z