Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. - Wikidata - awgldk - TriplyDB

Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

http://www.wikidata.org/entity/Q34581388

about

The value of trabectedin in the treatment of soft tissue sarcoma Trypanocidal activity of marine natural products Trabectedin in soft tissue sarcomas Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines Trabectedin and its potential in the treatment of soft tissue sarcoma.Trabectedin for the management of soft-tissue sarcoma.Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth Role of trabectedin in the treatment of soft tissue sarcoma Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor.Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex Trabectedin in the treatment of metastatic soft tissue sarcoma: cost-effectiveness, cost-utility and value of information.PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.Trabectedin: safety and efficacy in the treatment of advanced sarcoma Case Report of Suspected Rhabdomyolysis during Treatment with Trabectedin in a Patient with Metastatic Leiomyosarcoma Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104).Trabectedin as a single agent and in combination with pegylated liposomal doxorubicin - activity against ovarian cancer cells.Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancer BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas Wide-spectrum characterization of trabectedin: biology, clinical activity and future perspectives.Liposarcoma: molecular genetics and therapeutics.Clinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma.Safety evaluation of trabectedin in treatment of soft-tissue sarcomas.Trabectedin, a drug acting on both cancer cells and the tumour microenvironment.Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.ERCC5/XPG, ERCC1, and BRCA1 gene status and clinical benefit of trabectedin in patients with soft tissue sarcoma.Trabectedin for the treatment of breast cancer.Unique features of trabectedin mechanism of action.Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic cholangiocarcinoma paired patient derived xenograft and cell line.Trabectedin is a promising antitumour agent for synovial sarcoma.Trabectedin for the treatment of soft tissue sarcomas.Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway.Trabectedin for sarcomas in daily clinical practice: analysis of 45 patients treated in a French institution.

P2860

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P2860

Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

http://www.wikidata.org/entity/Q34581388

description

2007 nî lūn-bûn

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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2007 թվականի հուլիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Replication and homologous rec ...... r alkylator ecteinascidin 743.

@ast

Replication and homologous rec ...... r alkylator ecteinascidin 743.

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Replication and homologous rec ...... r alkylator ecteinascidin 743.

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type

label

Replication and homologous rec ...... r alkylator ecteinascidin 743.

@ast

Replication and homologous rec ...... r alkylator ecteinascidin 743.

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Replication and homologous rec ...... r alkylator ecteinascidin 743.

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prefLabel

Replication and homologous rec ...... r alkylator ecteinascidin 743.

@ast

Replication and homologous rec ...... r alkylator ecteinascidin 743.

@en

Replication and homologous rec ...... r alkylator ecteinascidin 743.

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PNAS.0609877104

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Replication and homologous rec ...... r alkylator ecteinascidin 743.

@en

P2093

Alain Sarasin

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Alexandre E Escargueil

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Annette K Larsen

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Daniele Grazziotin Soares

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Diego Bonatto

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João Antonio Pêgas Henriques

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P2860

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene

Solution structure of the monoalkylated mitomycin C-DNA complex

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.

Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.

Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence-selective DNA binding antitumor agent, hedamycin: evidence of survivin down-regulation associated with drug sensitivity

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.

Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients.

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13062-13067

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scholarly article

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10.1073/PNAS.0609877104

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32

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104

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Aimery de Gramont

Virginie Poindessous

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2007-07-26T00:00:00Z

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6181458

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1941813

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