Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex
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Trabectedin for Soft Tissue Sarcoma: Current Status and Future PerspectivesTrabectedin in soft tissue sarcomasEcteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cellsGammaH2AX and cancerTrabectedin for the management of soft-tissue sarcoma.Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cellsDual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growthHistone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stressComparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104).Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models.Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity.Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedinFocus on histone variant H2AX: to be or not to be.High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integrationEvaluation of surrogate tissues as indicators of drug activity in a melanoma skin modelDual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.Wide-spectrum characterization of trabectedin: biology, clinical activity and future perspectives.New emerging drugs targeting the genomic integrity and replication machinery in ovarian cancer.Liposarcoma: molecular genetics and therapeutics.Safety evaluation of trabectedin in treatment of soft-tissue sarcomas.Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.Unique features of trabectedin mechanism of action.Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic cholangiocarcinoma paired patient derived xenograft and cell line.Efficacy of trabectedin for the treatment of liposarcoma.Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells.Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity.Lsm1 promotes genomic stability by controlling histone mRNA decayThe Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instabilitySingle-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.A retrospective pooled analysis of trabectedin safety in 1,132 patients with solid tumors treated in phase II clinical trialsThe Cockayne syndrome protein B is involved in the repair of 5-AZA-2'-deoxycytidine-induced DNA lesions
P2860
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P2860
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@ast
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@en
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@nl
type
label
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@ast
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@en
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@nl
prefLabel
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@ast
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@en
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@nl
P2860
P356
P1476
Transcription-coupled DNA doub ...... d the Mre11-Rad50-Nbs1 complex
@en
P2093
Christophe Redon
Josée Guirouilh-Barbat
P2860
P304
P356
10.1091/MBC.E08-02-0215
P50
P577
2008-07-16T00:00:00Z