Computational approaches to the prediction of the blood-brain distribution.
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Identification of novel functional inhibitors of acid sphingomyelinasePhosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's diseaseComputational methods in drug discoveryMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsMolecular characterization of CYP2B6 substratesADMET evaluation in drug discovery. 12. Development of binary classification models for prediction of hERG potassium channel blockageKnowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug DiscoveryA crowdsourcing evaluation of the NIH chemical probesChallenges of using in vitro data for modeling P-glycoprotein efflux in the blood-brain barrier.Methods to assess drug permeability across the blood-brain barrier.Towards Better BBB Passage Prediction Using an Extensive and Curated Data Set.The acid-base profile of a contemporary set of drugs: implications for drug discovery.Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities studyNew predictive models for blood-brain barrier permeability of drug-like moleculesTissue concentration of systemically administered antineoplastic agents in human brain tumors.How to measure drug transport across the blood-brain barrierA method to predict blood-brain barrier permeability of drug-like compounds using molecular dynamics simulationsFree diffusion of steroid hormones across biomembranes: a simplex search with implicit solvent model calculationsStrategies for the generation, validation and application of in silico ADMET models in lead generation and optimization.Challenges for blood-brain barrier (BBB) screening.Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple SclerosisDifferential effects of procaspase-3 activating compounds in the induction of cancer cell death.Prediction methods and databases within chemoinformatics: emphasis on drugs and drug candidates.A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction.Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice.Improving the prediction of the brain disposition for orally administered drugs using BDDCS.Interpretation of antibiotic concentration ratios measured in epithelial lining fluid.Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsyModeling kinetics of subcellular disposition of chemicals.Modeling free energies of solvation in olive oil.The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug developmentImproving the prediction of drug disposition in the brain.Can we predict blood brain barrier permeability of ligands using computational approaches?Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain.In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans.TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation.Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.The forgotten or underestimated relevance of biopharmaceutical-based assessments for the oral absorption studies of oxime reactivators.Predict drug permeability to blood-brain-barrier from clinical phenotypes: drug side effects and drug indications.Integrated One-Against-One Classifiers as Tools for Virtual Screening of Compound Databases: A Case Study with CNS Inhibitors.
P2860
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P2860
Computational approaches to the prediction of the blood-brain distribution.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Computational approaches to the prediction of the blood-brain distribution.
@ast
Computational approaches to the prediction of the blood-brain distribution.
@en
Computational approaches to the prediction of the blood-brain distribution.
@nl
type
label
Computational approaches to the prediction of the blood-brain distribution.
@ast
Computational approaches to the prediction of the blood-brain distribution.
@en
Computational approaches to the prediction of the blood-brain distribution.
@nl
prefLabel
Computational approaches to the prediction of the blood-brain distribution.
@ast
Computational approaches to the prediction of the blood-brain distribution.
@en
Computational approaches to the prediction of the blood-brain distribution.
@nl
P1476
Computational approaches to the prediction of the blood-brain distribution.
@en
P2093
Markus Haeberlein
P304
P356
10.1016/S0169-409X(02)00005-4
P407
P50
P577
2002-03-01T00:00:00Z