Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy
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Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthaseMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsCrystal Structures of Constitutive Nitric Oxide Synthases in Complex with De Novo Designed Inhibitors †Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal ModelExploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine DerivativesImproved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide SynthaseCyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthaseIntramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthaseSimplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase InhibitionHypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test.Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Nitric oxide synthases activation and inhibition by metallacarborane-cluster-based isoform-specific affectors.Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthaseInvolvement of neuronal nitric oxide synthase in ongoing fetal brain injury following near-term rabbit hypoxia-ischemia.Neuronal nitric oxide synthase inhibition prevents cerebral palsy following hypoxia-ischemia in fetal rabbits: comparison between JI-8 and 7-nitroindazole.Acid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine DerivativesIncreased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid SystemTarget- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbersInhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase.Tyrosine phosphorylation of neuronal nitric oxide synthase (nNOS) during hypoxia in the cerebral cortex of newborn piglets: the role of nitric oxideDesign of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep.Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailabilityConcise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide.Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors.Nitric Oxide Production in the Striatum and Cerebellum of a Rat Model of Preterm Global Perinatal Asphyxia.Fragment informatics and computational fragment-based drug design: an overview and update.Systems biology of antioxidants.Arginine-based inhibitors of nitric oxide synthase: therapeutic potential and challenges.Nitric oxide signaling in the brain: a new target for inhaled nitric oxide?Nitric oxide synthase inhibitors: a review of patents from 2011 to the present.Nitric oxide synthase and structure-based inhibitor design.
P2860
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P2860
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy
@en
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
@nl
type
label
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy
@en
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
@nl
prefLabel
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy
@en
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
@nl
P2093
P2860
P356
P1433
P1476
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy
@en
P2093
Huiying Li
Jeannette Vásquez-Vivar
Jotaro Igarashi
Linda J Roman
Matthew Derrick
Pavel Martásek
Richard B Silverman
Sidhartha Tan
Thomas L Poulos
P2860
P304
P356
10.1002/ANA.21555
P577
2009-02-01T00:00:00Z