Target identification for small bioactive molecules: finding the needle in the haystack. - Wikidata - awgldk - TriplyDB

Target identification for small bioactive molecules: finding the needle in the haystack.

Target identification for small bioactive molecules: finding the needle in the haystack.

http://www.wikidata.org/entity/Q34589404

about

Discovery and resupply of pharmacologically active plant-derived natural products: A review Chemical proteomics approaches for identifying the cellular targets of natural products Target identification by image analysis Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome Considerations for designing chemical screening strategies in plant biology.In situ imaging and proteome profiling indicate andrographolide is a highly promiscuous compound.The Role of Historical Bioactivity Data in the Deconvolution of Phenotypic Screens.Potential strategies for increasing drug-discovery productivity.Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.Tetrazine ligation for chemical proteomics.Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products.Self-assembled nanoscale coordination polymers carrying siRNAs and cisplatin for effective treatment of resistant ovarian cancer.Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach.Shaping the interaction landscape of bioactive molecules.Discovery of a Potent Anti-tumor Agent through Regioselective Mono-N-acylation of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine.Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.Biological targets and mechanisms of action of natural products from marine cyanobacteria.Cancer stem cells as a target population for drug discovery.Drug affinity responsive target stability (DARTS) for small-molecule target identification.Protein homology reveals new targets for bioactive small molecules.Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery.Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions.Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60.Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing Target identification for biologically active small molecules using chemical biology approaches.A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition.Proteome-scale Binary Interactomics in Human Cells.Plant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology.Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane.Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.Label-free drug discovery.Label-free target identification using in-gel fluorescence difference via thermal stability shift.Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP).Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.Amorfrutins: A promising class of natural products that are beneficial to health.Target identification strategies in plant chemical biology.

P2860

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P2860

Target identification for small bioactive molecules: finding the needle in the haystack.

http://www.wikidata.org/entity/Q34589404

description

2013 nî lūn-bûn

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2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Target identification for small bioactive molecules: finding the needle in the haystack.

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Christian Hedberg

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Slava Ziegler

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Verena Pries

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P2860

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

Identification of direct protein targets of small molecules

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding

Identification of a primary target of thalidomide teratogenicity

Small-molecule inhibition of APT1 affects Ras localization and signaling

Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Haploid genetic screens in human cells identify host factors used by pathogens

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Herbert Waldmann

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