High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase
about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisGenetic architecture of local adaptation in lunar and diurnal emergence times of the marine midge Clunio marinus (Chironomidae, Diptera)The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1Clinical management of sleep disturbances in Alzheimer's disease: current and emerging strategiesPharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapyMolecular architecture of the mammalian circadian clockCircadian clock control of endocrine factorsSleep, circadian rhythms, and the pathogenesis of Alzheimer diseaseChemical chronobiology: Toward drugs manipulating time.Manipulating the circadian and sleep cycles to protect against metabolic diseaseEmerging models for the molecular basis of mammalian circadian timingCircadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: insights from a transgenic mouse modelInhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney DiseaseThe reduced kinome of Ostreococcus tauri: core eukaryotic signalling components in a tractable model speciesSelenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana.Speed control: cogs and gears that drive the circadian clock.Identification of small molecule activators of cryptochromeSmall molecule modifiers of circadian clocks.A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function.The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactionsSystems Biology-Derived Discoveries of Intrinsic Clocks.Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.Target identification for small bioactive molecules: finding the needle in the haystack.Global approaches for telling time: omics and the Arabidopsis circadian clockAmplitude metrics for cellular circadian bioluminescence reporters.Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.Estimating confidence intervals in predicted responses for oscillatory biological modelsFunctional analysis of Casein Kinase 1 in a minimal circadian systemRobust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells.Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga.Circadian clock disruption in neurodegenerative diseases: cause and effect?Advancing respiratory researchCircadian metabolism in the light of evolutionIdentification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening.Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes.Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock.Monitoring cell-autonomous circadian clock rhythms of gene expression using luciferase bioluminescence reportersGenetic insights on sleep schedules: this time, it's PERsonal.The mammalian clock and chronopharmacology
P2860
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P2860
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
High-throughput chemical scree ...... α as a clock regulatory kinase
@ast
High-throughput chemical scree ...... α as a clock regulatory kinase
@en
High-throughput chemical scree ...... α as a clock regulatory kinase
@en-gb
High-throughput chemical scree ...... α as a clock regulatory kinase
@nl
type
label
High-throughput chemical scree ...... α as a clock regulatory kinase
@ast
High-throughput chemical scree ...... α as a clock regulatory kinase
@en
High-throughput chemical scree ...... α as a clock regulatory kinase
@en-gb
High-throughput chemical scree ...... α as a clock regulatory kinase
@nl
altLabel
High-Throughput Chemical Scree ...... α as a Clock Regulatory Kinase
@en
prefLabel
High-throughput chemical scree ...... α as a clock regulatory kinase
@ast
High-throughput chemical scree ...... α as a clock regulatory kinase
@en
High-throughput chemical scree ...... α as a clock regulatory kinase
@en-gb
High-throughput chemical scree ...... α as a clock regulatory kinase
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
High-throughput chemical scree ...... α as a clock regulatory kinase
@en
P2093
David Traver
Eric C Peters
Jae Wook Lee
Jean-Pierre Etchegaray
Michael Garcia
Peter G Schultz
Steve A Kay
Xianzhong Liu
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1000559
P407
P577
2010-12-14T00:00:00Z