RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
about
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyCell Proliferation in NeuroblastomaStructure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapiesTime-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdownChemical strategies for development of ATR inhibitorsRoles of Chk1 in cell biology and cancer therapyChk1 targeting reactivates PP2A tumor suppressor activity in cancer cellsHigh-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancerInhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsOverview and recent advances in the treatment of neuroblastoma.Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpointsClassification of tumor samples from expression data using decision trunks.11q deletion in neuroblastoma: a review of biological and clinical implications.Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.New aspects of neuroblastoma treatment: ASPHO 2011 symposium reviewChk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer.Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo.An arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidatesTargeting Epigenetic Pathways in the Treatment of Pediatric Diffuse (High Grade) Gliomas.Therapeutic targets for neuroblastomas.A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy.Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma.Targeting lung cancer through inhibition of checkpoint kinases.DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.Management of high-grade gliomas in the pediatric patient: Past, present, and future.Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cellsmTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibitionAurora B kinase is a potent and selective target in MYCN-driven neuroblastomaMiR-195 suppresses non-small cell lung cancer by targeting CHEK1.DNA Damage and Repair Biomarkers in Cervical Cancer Patients Treated with Neoadjuvant Chemotherapy: An Exploratory Analysis.Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.Molecular profiling of childhood cancer: Biomarkers and novel therapiesCyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent NeuroblastomaMolecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma.CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells.
P2860
Q26745686-5292CCB3-4311-4372-AF55-A3027663C5B8Q26771708-449C1AA1-C774-453C-A8B3-7BCD09A6FA34Q26864870-D6546071-6C47-4150-8074-BE8A5F524842Q27332436-44141A80-37A9-4607-9C0C-10EEE3F46C20Q28239738-878BAA1E-6736-485D-A797-8495BF42045BQ28289548-FC3FDDED-D24A-49BD-96E0-98480D0BEA66Q28299365-5F2B3142-E9B5-413A-A19D-1CE532E0FF0CQ28480861-87184BFB-D534-4D86-8E86-F1829DF98042Q28817295-2E5A65CB-C774-49CC-8403-92073A6FABE6Q30238693-66048AE6-CB97-41F2-950F-FBEB4C86EA5CQ30426051-61B15F83-6743-4D7C-840F-538393660638Q30584974-4169F95B-4F8E-4ED5-A69E-D8D99459A0CCQ30596903-21C19984-ED16-4AA8-8B67-39DFD5488C8FQ32174267-64988DE1-9492-4E6E-B6BF-AE21CE8E66B1Q33578581-77184CCB-DD49-4502-A157-F50057337222Q33922797-61462DB6-3CEC-49FD-A447-D10FE5BB017BQ34028486-D59D82EB-E165-442D-BFB9-4B736A8EE9C2Q34062570-E8EAFB86-48C3-4167-AA62-75EE0A4E2C90Q34309214-D5852CBB-EB4A-4B11-904B-8BD023DB959FQ34496715-A5C665CB-8E54-4DA9-BC92-B153716B6B14Q34552042-DD2C5CE9-10A9-434B-8117-4560E6DD8508Q34560877-5D3F0BB4-BD96-4190-9617-69A58D8F0567Q34618606-9D69D267-FDC0-49EE-8C5E-6F22CC132BE2Q35070321-12FA53F5-341D-4C4B-B9B7-BCB1065DE37FQ35128547-FD5FA367-1A14-4253-8903-123FF136A3C7Q35172709-0258EB5A-9603-4BBC-BF96-637F411078D7Q35206259-F9140789-F07D-42A8-AE2F-AA41F5BFA944Q35657580-30E28EC6-830E-4490-A041-21EB0A215DEFQ35745476-60567044-E2EE-4192-961E-79A6351DF0D5Q35809470-E9B6FA69-CAA2-44CB-AF80-05F53665F4B2Q35819646-B643ED8B-2610-4AF6-851F-1AD9751D6FBAQ35832394-DA5A8ACF-C372-49BA-9ECC-121173653FA1Q35941085-CA2DAB54-FB4F-4B15-8A20-AFEB700161B8Q36187661-7CD0514D-7751-4958-8386-6E100E22391BQ36250783-6D8BB858-7DC2-4BB4-B7F4-05D062B61B35Q36281460-A09F1C36-C25F-4949-BDD0-B70E58AC4BBCQ36313712-472DBD0E-1E01-4B95-A093-C32D9C37E45BQ36328196-52AD8F1E-D63B-4F29-9EA4-411FD8AFF8CEQ36378134-89FF63BD-3565-44DE-B1CB-25E36ECE46C4Q36437713-CB11934E-60AB-41D5-9680-88B8E7BABDEC
P2860
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
RNAi screen of the protein kin ...... peutic target in neuroblastoma
@ast
RNAi screen of the protein kin ...... peutic target in neuroblastoma
@en
RNAi screen of the protein kinome identifies checkpoint kinase 1
@nl
type
label
RNAi screen of the protein kin ...... peutic target in neuroblastoma
@ast
RNAi screen of the protein kin ...... peutic target in neuroblastoma
@en
RNAi screen of the protein kinome identifies checkpoint kinase 1
@nl
prefLabel
RNAi screen of the protein kin ...... peutic target in neuroblastoma
@ast
RNAi screen of the protein kin ...... peutic target in neuroblastoma
@en
RNAi screen of the protein kinome identifies checkpoint kinase 1
@nl
P2093
P2860
P356
P1476
RNAi screen of the protein kin ...... peutic target in neuroblastoma
@en
P2093
Andrew C Wood
Chase E Hulderman
Cynthia Winter
Edward F Attiyeh
Geoffrey Norris
Jayanti Jagannathan
John M Maris
Jonathan Huggins
Kristina A Cole
Kristopher Bosse
P2860
P304
P356
10.1073/PNAS.1012351108
P407
P577
2011-02-02T00:00:00Z