An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage
about
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathwaysBlocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanismHost modulators of H1N1 cytopathogenicityThe potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffoldsThe effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivityATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway functionFanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1Importance of a C-terminal conserved region of Chk1 for checkpoint function.Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.DNA sequence recognition by the indolocarbazole antitumor antibiotic AT2433-B1 and its diastereoisomer.Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domainGenetic mutation analysis of human gastric adenocarcinomas using ion torrent sequencing platform.p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cellsGABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epitheliumInfluence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines.Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection.RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastomaLack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells.CK1δ kinase activity is modulated by Chk1-mediated phosphorylation.Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe.The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathwayFen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancerChemotherapeutic approaches for targeting cell death pathways.CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells.The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrestTherapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold.Structure elucidation and anticancer activity of 7-oxostaurosporine derivatives from the Brazilian endemic tunicate Eudistoma vannamei.The use of novel selectivity metrics in kinase research.Regulation of Chk1 by its C-terminal domain.Long-term administration of artesunate induces reproductive toxicity in male ratsStaurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent mannerDamage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activityKCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment.p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
P2860
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P2860
An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage
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2000 nî lūn-bûn
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An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
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An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
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An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
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label
An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
@ast
An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
@en
An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
@nl
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An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
@ast
An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
@en
An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
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P2093
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An indolocarbazole inhibitor o ...... le arrest caused by DNA damage
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P2093
A Gilmartin
C Imburgia
J D Winkler
J R Jackson
L A Marshall
P304
P3181
P407
P577
2000-02-01T00:00:00Z