Promotion of sleep by targeting the orexin system in rats, dogs and humans.
about
Orexin receptors: pharmacology and therapeutic opportunitiesPharmacological validation of candidate causal sleep genes identified in an N2 crossControl of sleep and wakefulnessIn vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide SThe orexin-1 antagonist SB-334867 blocks antipsychotic treatment emergent catalepsy: implications for the treatment of extrapyramidal symptomsPhysiology of the orexinergic/hypocretinergic system: a revisit in 2012Energy expenditure: role of orexinThe hypocretins/orexins: integrators of multiple physiological functionsThe role of orexin in post-stroke inflammation, cognitive decline, and depressionOrexin antagonists for neuropsychiatric disease: progress and potential pitfallsMultiple roles for orexin/hypocretin in addictionDual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor aloneOrexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexantPhase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonistDifferential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomniaDiscovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaFunctional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonistsThe dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administrationDexamethasone Chemotherapy Does Not Disrupt Orexin SignalingThe Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in MonkeysDifferential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulatorsCentral chemoreceptors: locations and functions.Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: their potential role in sickness behaviorOrexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs.The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking.A key role for orexin in panic anxiety.Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle.Neurogenesis-independent antidepressant-like effects on behavior and stress axis response of a dual orexin receptor antagonist in a rodent model of depression.Evaluation of potential PET imaging probes for the orexin 2 receptors.LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy.Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in miceRapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beadsOptogenetic deconstruction of sleep-wake circuitry in the brainOrexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.Advances in the management of insomniaThe orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle.Quantitative proteomics in laser capture microdissected sleep nuclei from rat brain.Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin.
P2860
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P2860
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@ast
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@en
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@nl
type
label
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@ast
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@en
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@nl
prefLabel
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@ast
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@en
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@nl
P2093
P356
P1433
P1476
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
@en
P2093
Catherine Brisbare-Roch
Celia Mueller
Changbin Qiu
François Jenck
Hamed Aissaoui
Jasper Dingemanse
Joop van Gerven
Martine Clozel
Michael Scherz
Oliver Nayler
P2888
P304
P356
10.1038/NM1544
P407
P577
2007-01-28T00:00:00Z