Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions
about
Yeast: a simple model system to study complex phenomena of aneuploidyRe-replication of a centromere induces chromosomal instability and aneuploidyThe ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesionELG1, a yeast gene required for genome stability, forms a complex related to replication factor CGenetic instability in budding and fission yeast-sources and mechanismsAneuploidy and improved growth are coincident but not causal in a yeast cancer model.Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiaeChromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms.RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instabilityCycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast.High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IVSelection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiaeA Rad53 independent function of Rad9 becomes crucial for genome maintenance in the absence of the Recq helicase Sgs1A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae.Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombinationChanges in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemia.Reciprocal uniparental disomy in yeastSrs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability.High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strainsMrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage.RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiaeMutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption.An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses.Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae.Genome instability in rad54 mutants of Saccharomyces cerevisiae.The checkpoint protein Rad24 of Saccharomyces cerevisiae is involved in processing double-strand break ends and in recombination partner choice.Virulence and karyotype analyses of rad52 mutants of Candida albicans: regeneration of a truncated chromosome of a reintegrant strain (rad52/RAD52) in the host.The spindle assembly checkpoint regulates the phosphorylation state of a subset of DNA checkpoint proteins in Saccharomyces cerevisiaeLoss and fragmentation of chromosome 5 are major events linked to the adaptation of rad52-DeltaDelta strains of Candida albicans to sorboseMrc1 and Srs2 are major actors in the regulation of spontaneous crossover.Rad52 function prevents chromosome loss and truncation in Candida albicans.
P2860
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P2860
Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions
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2001 nî lūn-bûn
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2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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Spontaneous chromosome loss in ...... NA damage checkpoint functions
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2001-12-01T00:00:00Z