A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor
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Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsAutoimmunity and Graves' diseaseThyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves' DiseaseStructural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkSmall molecule TSHR agonists and antagonists.Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes.Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves' disease immunoglobinsTargeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodiesIncreased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production.Immunopathogenesis of Graves' ophthalmopathy: the role of the TSH receptor.Forkhead Transcription Factor FOXO1 Is Regulated by Both a Stimulatory Thyrotropin Receptor Antibody and Insulin-Like Growth Factor-1 in Orbital Fibroblasts from Patients with Graves' Ophthalmopathy.A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptorCurrent concepts in graves' disease.Update in TSH receptor agonists and antagonistsA small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy.Novel insights on thyroid-stimulating hormone receptor signal transduction.A selective TSH receptor antagonist inhibits stimulation of thyroid function in female miceA modified ELISA accurately measures secretion of high molecular weight hyaluronan (HA) by Graves' disease orbital cells.Emerging pharmacotherapy for treatment of Graves' diseaseRegulation of IL-1 receptor antagonist by TSH in fibrocytes and orbital fibroblasts.Review of Mouse Models of Graves' Disease and Orbitopathy-Novel Treatment by Induction of Tolerance.Targeting the thyrotropin receptor in thyroid disease.Neutralization of anticitrullinated protein antibodies in rheumatoid arthritis - a way to go?An update on the medical treatment of Graves' hyperthyroidism.Pathogenesis of thyroid eye disease: review and update on molecular mechanisms.Current trends in antithyroid drug treatment of Graves' disease.TSHR as a therapeutic target in Graves' disease.Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor.Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future.
P2860
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P2860
A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A new small-molecule antagonis ...... activation of the TSH receptor
@ast
A new small-molecule antagonis ...... activation of the TSH receptor
@en
A new small-molecule antagonis ...... activation of the TSH receptor
@nl
type
label
A new small-molecule antagonis ...... activation of the TSH receptor
@ast
A new small-molecule antagonis ...... activation of the TSH receptor
@en
A new small-molecule antagonis ...... activation of the TSH receptor
@nl
prefLabel
A new small-molecule antagonis ...... activation of the TSH receptor
@ast
A new small-molecule antagonis ...... activation of the TSH receptor
@en
A new small-molecule antagonis ...... activation of the TSH receptor
@nl
P2093
P2860
P356
P1476
A new small-molecule antagonis ...... activation of the TSH receptor
@en
P2093
Cesidio Giuliani
Elena Eliseeva
Fabrizio Monaco
Giorgio Napolitano
Joshua G McCoy
Marvin C Gershengorn
Susanne Neumann
Wenwei Huang
P2860
P304
P356
10.1210/JC.2010-1935
P407
P577
2010-12-01T00:00:00Z