A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
about
Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkSmall molecule TSHR agonists and antagonists.Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization.A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptorMutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signalingA drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptorCurrent concepts in graves' disease.A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy.Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibitionA selective TSH receptor antagonist inhibits stimulation of thyroid function in female miceTargeting the thyrotropin receptor in thyroid disease.TSHR as a therapeutic target in Graves' disease.Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future.
P2860
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P2860
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
@ast
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
@en
type
label
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
@ast
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
@en
prefLabel
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
@ast
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
@en
P2093
P2860
P356
P1433
P1476
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor
@en
P2093
Craig J Thomas
Elena Eliseeva
Marvin C Gershengorn
Steve Titus
Susanne Neumann
Wenwei Huang
P2860
P304
P356
10.1210/EN.2010-0199
P407
P577
2010-04-28T00:00:00Z