Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids. - Wikidata - awgldk - TriplyDB

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

http://www.wikidata.org/entity/Q34624351

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Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle Leucine signaling in the pathogenesis of type 2 diabetes and obesity The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes.A High-Protein Diet Reduces Weight Gain, Decreases Food Intake, Decreases Liver Fat Deposition, and Improves Markers of Muscle Metabolism in Obese Zucker Rats.Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy.Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.Cardiac insulin resistance and microRNA modulators.Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes.Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides.Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine.Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet.Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes.The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.Nutritionally essential amino acids and metabolic signaling in aging.Effect of degree of hydrolysis of whey protein on in vivo plasma amino acid appearance in humans.Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways.Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress.Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs.Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius.Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism.The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling.Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?Knowledge gained from studies of leucine consumption in animals and humans.Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment.RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.Androgen-mediated regulation of skeletal muscle protein balance.Advance of autophagy in chronic kidney diseases.Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).Castration alters protein balance after high-frequency muscle contraction.Considerations on mTOR regulation at serine 2448: implications for muscle metabolism studies.Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia.Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.Eight Weeks of Phosphatidic Acid Supplementation in Conjunction with Resistance Training Does Not Differentially Affect Body Composition and Muscle Strength in Resistance-Trained Men

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Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

http://www.wikidata.org/entity/Q34624351

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

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2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@ast

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@en

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@nl

type

label

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@ast

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@en

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@nl

prefLabel

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@ast

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@en

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@nl

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JBC.M110.209171

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Journal of Biological Chemistry

P1476

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

@en

P2093

Jamie I Baum

http://www.w3.org/2001/XMLSchema#string

Leonard S Jefferson

http://www.w3.org/2001/XMLSchema#string

Michael D Dennis

http://www.w3.org/2001/XMLSchema#string

Scot R Kimball

http://www.w3.org/2001/XMLSchema#string

P2860

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

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8287-8296

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scholarly article

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10.1074/JBC.M110.209171

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10

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286

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21239491

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3048714

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