Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.
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Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet MimicsAmyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicityAn Atomistic View of Amyloidogenic Self-assembly: Structure and Dynamics of Heterogeneous Conformational States in the Pre-nucleation Phase.Intrinsic fibrillation of fast-acting insulin analogs.Giant macrolactams based on β-sheet peptides.Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly."Janus" cyclic peptides: a new approach to amyloid fibril inhibition?Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation.Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formationHeterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one.Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease.The supramolecular chemistry of β-sheets.In silico cross seeding of Aβ and amylin fibril-like oligomers.Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet.Design, synthesis, antifungal activities and 3D-QSAR of new N,N'-diacylhydrazines containing 2,4-dichlorophenoxy moiety.Polymorphism of oligomers of a peptide from β-amyloid.Observation of molecular inhibition and binding structures of amyloid peptides.Potential synergy between tau aggregation inhibitors and tau chaperone modulators.Capping parallel β-sheets of acetyl(Ala)6NH2 with an acetyl(Ala)5ProNH2 can arrest the growth of the sheet, suggesting a potential for curtailing amyloid growth. An ONIOM and density functional theory study.Rational design of an orthosteric regulator of hIAPP aggregation.Tau-derived-hexapeptide 306VQIVYK311 aggregation inhibitors: nitrocatechol moiety as a pharmacophore in drug designTwo-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitorDesign, synthesis, biological activities and 3D-QSAR of new N,N'-diacylhydrazines containing 2,4-dichlorophenoxy moieties.Inhibiting and reversing amyloid-β peptide (1-40) fibril formation with gramicidin S and engineered analogues.Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids.Zn2+ Interrupts R4-R3 Association Leading to Accelerated Aggregation of Tau Protein.Structure-based inhibitors of tau aggregation.New diketopiperazines as vectors for peptide protection and brain delivery: Synthesis and biological evaluation.Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues.Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity.A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde.Synthesis and conformational studies of a stable peptidomimetic β-hairpin based on a bifunctional diketopiperazine turn inducerCyclic Peptides as Inhibitors of Amyloid Fibrillation
P2860
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P2860
Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@ast
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@en
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@nl
type
label
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@ast
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@en
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@nl
prefLabel
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@ast
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@en
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@nl
P2093
P2860
P356
P1476
Macrocyclic β-sheet peptides t ...... u-protein-derived hexapeptide.
@en
P2093
Balraju Vadla
David Eisenberg
James S Nowick
Jing Zheng
R Jeremy Woods
Shafiullah Khan
Warren J Goux
P2860
P304
P356
10.1021/JA110545H
P407
P577
2011-02-14T00:00:00Z