Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation.
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Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domainVariant Bernard-Soulier syndrome type bolzano. A congenital bleeding disorder due to a structural and functional abnormality of the platelet glycoprotein Ib-IX complexSpecific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complexSequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbanceGlycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathwayPersistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogenRole of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.Stimulation of platelet apoptosis by peptidoglycan from Staphylococcus aureus 113.Alternate considerations for current concepts in ITP.Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.Low shear stress can initiate von Willebrand factor-dependent platelet aggregation in patients with type IIB and platelet-type von Willebrand disease.Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta).The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stressvon Willebrand factor binding to platelet GpIb initiates signals for platelet activation.Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIaInvolvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia.Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptorsSite-specific analysis of von Willebrand factor O-glycosylation.Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression modelFunctional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to plateletsRole of cellular elements in thrombus formation and dissolution.Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation.von Willebrand factor and platelet function.Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndromeInteraction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear.Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides.The cytoplasmic domain of the alpha-subunit of glycoprotein (GP) Ib mediates attachment of the entire GP Ib-IX complex to the cytoskeleton and regulates von Willebrand factor-induced changes in cell morphology.Glycans and the platelet life cycle.A biophysical view on von Willebrand factor activation.A monoclonal antibody recognizes a von Willebrand factor domain within the amino-terminal portion of the subunit that modulates the function of the glycoprotein IB- and IIB/IIIA-binding domains.Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expressionA critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications.Evaluation of platelet surface glycoproteins in patients with Glanzmann thrombasthenia: Association with bleeding symptoms.Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal.A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.
P2860
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P2860
Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation.
description
1985 nî lūn-bûn
@nan
1985 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
Interaction of asialo von Will ...... mediates platelet aggregation.
@ast
Interaction of asialo von Will ...... mediates platelet aggregation.
@en
Interaction of asialo von Will ...... mediates platelet aggregation.
@nl
type
label
Interaction of asialo von Will ...... mediates platelet aggregation.
@ast
Interaction of asialo von Will ...... mediates platelet aggregation.
@en
Interaction of asialo von Will ...... mediates platelet aggregation.
@nl
prefLabel
Interaction of asialo von Will ...... mediates platelet aggregation.
@ast
Interaction of asialo von Will ...... mediates platelet aggregation.
@en
Interaction of asialo von Will ...... mediates platelet aggregation.
@nl
P2093
P2860
P356
P1476
Interaction of asialo von Will ...... mediates platelet aggregation.
@en
P2093
A Girolami
L De Marco
Z M Ruggeri
P2860
P304
P356
10.1172/JCI111816
P407
P577
1985-04-01T00:00:00Z