Mapping the cellular response to small molecules using chemogenomic fitness signatures. - Wikidata - awgldk - TriplyDB

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

http://www.wikidata.org/entity/Q34626429

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Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?Mitochondrial targets for pharmacological intervention in human disease Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screens Biological data analysis as an information theory problem: multivariable dependence measures and the shadows algorithm High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines Chemogenomics and orthology-based design of antibiotic combination therapies Phosphatidylinositol transfer proteins and instructive regulation of lipid kinase biology Experimental and Computational Analysis of a Large Protein Network That Controls Fat Storage Reveals the Design Principles of a Signaling Network Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors.Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes.Systems cell biology.The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.Off-target effects of the septin drug forchlorfenuron on nonplant eukaryotes Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.Protein homology reveals new targets for bioactive small molecules.Rapid quantification of mutant fitness in diverse bacteria by sequencing randomly bar-coded transposons.Identification of a Mitochondrial DNA Polymerase Affecting Cardiotoxicity of Sunitinib Using a Genome-Wide Screening on S. pombe Deletion Library.Beyond Agar: Gel Substrates with Improved Optical Clarity and Drug Efficiency and Reduced Autofluorescence for Microbial Growth Experiments.Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells.Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae Network-assisted target identification for haploinsufficiency and homozygous profiling screens.Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress.High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance.A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction Predicting chemotherapeutic drug combinations through gene network profiling Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting.Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems Systematic identification and correction of annotation errors in the genetic interaction map of Saccharomyces cerevisiae.Utilizing yeast chemogenomic profiles for the prediction of pharmacogenomic associations in humans.Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis Transcriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response.

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Mapping the cellular response to small molecules using chemogenomic fitness signatures.

http://www.wikidata.org/entity/Q34626429

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@ast

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@en

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@nl

type

label

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@ast

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@en

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@nl

prefLabel

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@ast

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@en

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

@nl

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Mapping the cellular response to small molecules using chemogenomic fitness signatures.

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Ana Maria Aparicio

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Anna Y Lee

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Anuradha Surendra

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Chris A Kaiser

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Corey Nislow

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Elena Lissina

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Eric D Spear

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Eula Fung

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Geoffrey Duby

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Guri Giaever

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P2860

Open Babel: An open chemical toolbox

HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity

Cystic fibrosis in an era of genomically guided therapy

Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily

Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

Functional profiling of the Saccharomyces cerevisiae genome

Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae.

Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth.

Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo.

Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein.

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208-211

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scholarly article

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10.1126/SCIENCE.1250217

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344

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Carolyn L. Cummins

Lawrence E Heisler

Paul A. Spagnuolo

Mitchell K L Han

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2014-04-01T00:00:00Z

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261605250

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24723613

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