Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
about
Mutant p53: One, No One, and One Hundred ThousandTethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase.TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.TOPBP1 takes RADical command in recombinational DNA repairMutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer.
P2860
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P2860
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
description
2014 nî lūn-bûn
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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@ast
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@en
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
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label
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@ast
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@en
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@nl
prefLabel
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@ast
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@en
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@nl
P2093
P2860
P356
P1476
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
@en
P2093
Fang-Tsyr Lin
Gregory E Lin
Pinki Chowdhury
Weei-Chin Lin
Yongcheng Song
P2860
P2888
P356
10.1038/NCOMMS6476
P407
P577
2014-11-17T00:00:00Z
P5875
P6179
1001231861