about
Chemical biology approaches for the study of apicomplexan parasitesNew in vitro phenotypic assay for epilepsy: fluorescent measurement of synchronized neuronal calcium oscillationsTowards structural systems pharmacology to study complex diseases and personalized medicineLigand-target prediction by structural network biology using nAnnoLyzeThe state of the art of odorant receptor deorphanization: a report from the orphanageConsiderations for designing chemical screening strategies in plant biology.[Phenotypic screens or one stone to kill two birds: discover the target and its pharmacological regulator].Small molecule screening in human induced pluripotent stem cell-derived terminal cell types.Identifying Small Molecules which Inhibit Autophagy: a Phenotypic Screen Using Image-Based High-Content Cell Analysis.Improving detection of rare biological events in high-throughput screens.Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac DifferentiationThe Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases.Label-free drug discovery.Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP).Neural stem cells as tools for drug discovery: novel platforms and approaches.Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.Biological networks and drug discovery--where do we stand?Novel methods and approaches to acute lymphoblastic leukemia drug discovery.The use of high-throughput screening in identifying chemotherapeutic agents for gastric cancer.Anthelmintic drug discovery: into the future.Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery.Compound annotation with real time cellular activity profiles to improve drug discovery.Developing predictive assays: the phenotypic screening "rule of 3".Affinity purification in target identification: the specificity challenge.Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology.Patient-derived induced pluripotent stem cells in cancer research and precision oncology.LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor.Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits.Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to Xenopus laevis Phenotypic Readouts.Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay.Anticancer metallohelices: nanomolar potency and high selectivity.The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine.Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy.Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The why and how of phenotypic small-molecule screens.
@ast
The why and how of phenotypic small-molecule screens.
@en
The why and how of phenotypic small-molecule screens.
@nl
type
label
The why and how of phenotypic small-molecule screens.
@ast
The why and how of phenotypic small-molecule screens.
@en
The why and how of phenotypic small-molecule screens.
@nl
prefLabel
The why and how of phenotypic small-molecule screens.
@ast
The why and how of phenotypic small-molecule screens.
@en
The why and how of phenotypic small-molecule screens.
@nl
P2860
P356
P1476
The why and how of phenotypic small-molecule screens.
@en
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1206
P577
2013-04-01T00:00:00Z