Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines
about
DNA repair targeted therapy: The past or future of cancer treatment?Base excision repair and cancerFunctional DNA repair signature of cancer cell lines exposed to a set of cytotoxic anticancer drugs using a multiplexed enzymatic repair assay on biochipTargeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathySynthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.Saccharomyces cerevisiae as a model system to study the response to anticancer agents.Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsDesign and activity of AP endonuclease-1 inhibitors.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsRepair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomideIntratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma.Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.DNA damage tolerance: a double-edged sword guarding the genomeHuman apurinic/apyrimidinic endonuclease 1.Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.DNA Repair Endonucleases: Physiological Roles and Potential as Drug Targets.Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1.Methoxyamine sensitizes the resistant glioblastoma T98G cell line to the alkylating agent temozolomide.AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.Efficient inhibition of human AP endonuclease 1 (APE1) via substrate masking by abasic site-binding macrocyclic ligands.Large negatively charged organic host molecules as inhibitors of endonuclease enzymes
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Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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Development and evaluation of ...... melanoma and glioma cell lines
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D M Wilson
I D Hickson
M Z Mohammed
V N Vyjayanti
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10.1038/SJ.BJC.6606058
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2011-01-25T00:00:00Z
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1018272055