Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.
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Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidineMutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.HIV-1 Transmission, Replication Fitness and Disease Progression.Increased misincorporation fidelity observed for nucleoside analog resistance mutations M184V and E89G in human immunodeficiency virus type 1 reverse transcriptase does not correlate with the overall error rate measured in vitroThe P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activitiesTribute to Mark WainbergMutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase.Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase.Understanding HIV resistance, fitness, replication capacity and compensation: targeting viral fitness as a therapeutic strategy.Retrovirus reverse transcriptases containing a modified YXDD motif.Bayesian network analyses of resistance pathways against efavirenz and nevirapine.Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophageMutation rates and intrinsic fidelity of retroviral reverse transcriptases.The glutamine side chain at position 91 on the β5a-β5b loop of human immunodeficiency virus type 1 reverse transcriptase is required for stabilizing the dNTP binding pocket.Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergoing combination therapy: survey of 787 sequences.The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis.The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates.Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity.Mutational analysis of HIV-1 long terminal repeats to explore the relative contribution of reverse transcriptase and RNA polymerase II to viral mutagenesis.Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase.The impact of the M184V substitution in HIV-1 reverse transcriptase on treatment response.Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.Dominance of the E89G substitution in HIV-1 reverse transcriptase in regard to increased polymerase processivity and patterns of pausing.Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
P2860
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P2860
Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@ast
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@en
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@nl
type
label
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@ast
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@en
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@nl
prefLabel
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@ast
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@en
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@nl
P2093
P2860
P356
P1476
Higher fidelity of RNA-depende ...... immunodeficiency virus type 1.
@en
P2093
Wainberg MA
P2860
P304
P356
10.1093/NAR/25.22.4532
P407
P577
1997-11-01T00:00:00Z