New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. - Wikidata - awgldk - TriplyDB

New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.

New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.

http://www.wikidata.org/entity/Q34647592

about

The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor Mechanism and evolution of DNA primases Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families New strategies against drug resistance to herpes simplex virus The DNA helicase-primase complex as a target for herpes viral infection Current and potential treatments for ubiquitous but neglected herpesvirus infections Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.Role of RNA helicases in HIV-1 replication Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 Replication Novel agents and strategies to treat herpes simplex virus infections.Agents and strategies in development for improved management of herpes simplex virus infection and disease.Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections.Inhibition of the herpes simplex virus type 1 DNA polymerase induces hyperphosphorylation of replication protein A and its accumulation at S-phase-specific sites of DNA damage during infection.ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled.Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.Mutations in the putative zinc-binding motif of UL52 demonstrate a complex interdependence between the UL5 and UL52 subunits of the human herpes simplex virus type 1 helicase/primase complex.A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives.Emerging drugs for varicella-zoster virus infections.A cutting-edge view on the current state of antiviral drug development.Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1.Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293.Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice.Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13.Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling.Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles.Helicases as antiviral drug targets.Update on emerging antivirals for the management of herpes simplex virus infections: a patenting perspective.Progress in the development of new therapies for herpesvirus infections Discovering new medicines targeting helicases: challenges and recent progress.Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.Development of new antivirals for herpesviruses.Non-axial view of the varicella-zoster virus portal protein reveals conserved crown, wing and clip architecture.Helicase primase: targeting the Achilles heel of herpes simplex viruses.Antivirals and antiviral strategies.A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently.Update on new antivirals under development for the treatment of double-stranded DNA virus infections

P2860

Q24558692-B765B087-248D-48EE-AD2A-22F8B9CEBE2D Q24612068-D114F419-A5E9-478F-BAD7-2B3403115757 Q26700087-0FF10761-5409-4FDF-A7DF-B616A07F1343 Q26749548-2D306270-3B91-4FF5-83BC-C5204BC4CCA3 Q26849412-835F64A0-F7C8-40BC-A1E9-26E03AAE5B8C Q27023452-22BAE820-5F72-48E7-929D-BD59C7D4C7DF Q27324453-C6FDC53F-1137-4697-8AB2-5015AE6655F8 Q27477537-16C0D634-9DCD-4BA6-825D-21FCC01CA2A0 Q27486874-0216B904-E5D2-4D01-A7B6-61A23E21896E Q30332444-810A09C3-7549-4FB0-B6BA-A3D17D373B15 Q30350341-EB06CB3D-3532-4E36-A118-FB62D528C598 Q30720731-3D68A855-7B02-48B3-94EA-DB1AF4A84C0D Q33214993-FDE7290D-DC43-4F83-8D82-047A703B0105 Q33699630-2B6D5645-7AD7-465D-A827-4818D8E89D22 Q33798406-C2EFFECA-1509-4D5E-9DAD-E11A1E8C7FEF Q33883880-2C1C66B9-56CC-467F-9757-FD22A8354288 Q33957538-2CA23DA8-4498-4411-ADD0-14CD78040BC4 Q34027426-11D83A30-4581-4B17-92F8-D59CF62D4F60 Q34036018-8C428F0C-978C-4646-AE42-F5C5B1113AF9 Q34056764-9D2F53F1-2C04-45A8-9FB9-493D4D19F7B1 Q34109321-2F98ECC7-8160-40F8-87AF-A2C6C620C08D Q34316979-4B32DCA9-0B26-44DD-96DE-729377D04761 Q34319607-353102FB-FCE7-471F-AE2A-D8FF20BD6DD8 Q34360183-71F37A40-D79B-4200-85CD-EE0B47E57AFC Q34368072-96D42204-8BB7-4600-93EB-9D27989F056E Q34468784-1F967E48-9978-49A8-8705-1BED83051C7A Q34607601-1449CB0C-84A0-45DA-9CD2-0852D06E539F Q35008795-4E64856F-9E9B-43A1-8978-74DE4F346566 Q35105400-49C224C0-6B93-48C3-A09D-304793989DBB Q35218580-D74C2D00-DDB9-4278-9683-42CF31567D9A Q35531731-F0CEE503-AF7F-4300-B843-542E9EAF2C2D Q35590695-B0C35A79-C713-4165-938F-25B5ABAC070F Q35592783-75114BF8-7601-48EB-8843-1ECEF82A702E Q35647755-3F756FDA-42A5-4910-9CF4-136A2B707605 Q35669533-4761790C-B52F-4D2B-B842-E3D1BDFF1459 Q35770254-1021F57D-38FC-4065-B1FB-004457F19E8E Q35842275-DAB380F9-DE13-45BE-95C6-532F5BE3ECEC Q35889586-2C968E4D-85FE-4211-931F-94B77143B6B6 Q35947833-2A0DF4DC-0F56-44D2-8988-61542AB27F7C Q36185647-138CEEF9-3A1F-4BBF-96B3-5D9DED50605E

P2860

New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.

http://www.wikidata.org/entity/Q34647592

description

2002 nî lūn-bûn

@nan

2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年学术文章

@wuu

2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

name

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@ast

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@en

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@nl

type

label

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@ast

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@en

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@nl

prefLabel

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@ast

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@en

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@nl

P1433

Q34647592-59E61CE2-14D9-41E3-B6BC-349F188A1A01

P1476

Q34647592-D6BBF5DD-B434-4792-8478-C02321748264

P2093

Q34647592-0977765D-4FC3-4A47-82AF-7A173C242212

Q34647592-110753F8-62EB-4AB2-8CD9-341DBBE49825

Q34647592-1368C002-42F8-426D-8F1B-BA1440E7FB5B

Q34647592-23D7B5E8-C228-4F32-B356-11ED29D78EE0

Q34647592-37D543A0-B108-4C5F-8F11-2BAA877A0699

Q34647592-63CAC208-1FF3-4669-A2D9-90B5B03556AA

Q34647592-6505FD06-2EDB-4FB5-9686-889E4B347C46

Q34647592-675FADD0-1B72-4A82-8B2D-0561B9E7908C

Q34647592-67748125-D5B6-488E-B0EB-83EFCAB84092

Q34647592-76579DB7-9B97-4C42-BA6F-14E2FAC514B5

P2860

Q34647592-17366257-0711-4E40-A0B7-23EBC1EF6D6E

Q34647592-3902A193-D78E-4E54-996C-BFC96F479F8F

Q34647592-3CE65CF7-4D8D-415C-B0FE-95DAD98A6E45

Q34647592-53BCD890-EDF9-4B51-8C54-1CFA5AC7A16B

Q34647592-7E3584BF-736A-452F-8444-ECD231EC009C

Q34647592-B3B16C90-C735-4B18-9C1E-5FDFB6BFEDAC

Q34647592-F188BAC9-A4A3-418D-BD59-DB9ADE9382D9

P2888

Q34647592-DD5FBD6A-BF3D-4A5C-BC40-A12F922D44BE

P304

Q34647592-6DF6046D-C521-48BD-9508-EB980DC83E8E

P31

Q34647592-B8E12F86-0772-4AAF-88E1-5305B76DD535

P356

Q34647592-ACD4BDD5-6D50-4153-BA24-C646FD7F48D6

P407

Q34647592-5624CD8B-4BF0-49BD-A978-CBFF916B9899

P433

Q34647592-7EC23A59-CE7E-4AC4-B94D-22C7782DB50C

P478

Q34647592-3EBC4C0C-EB47-4263-A5C9-B70EB3CBB3AF

P50

Q34647592-ECED8432-15EC-4F82-9283-9D93388B7DFB

P577

Q34647592-3335D09E-5879-47BB-8359-C06AD1493EC1

P698

Q34647592-63D684AE-1A72-40F9-89EC-E2AC6A625EB6

P356

P1433

Nature Medicine

P1476

New helicase-primase inhibitor ...... ent of herpes simplex disease.

@en

P2093

Andreas Popp

http://www.w3.org/2001/XMLSchema#string

Axel Jensen

http://www.w3.org/2001/XMLSchema#string

Dieter Haebich

http://www.w3.org/2001/XMLSchema#string

Gabriele Handke

http://www.w3.org/2001/XMLSchema#string

Gerald Kleymann

http://www.w3.org/2001/XMLSchema#string

Guy Hewlett

http://www.w3.org/2001/XMLSchema#string

Helga Rübsamen-Waigmann

http://www.w3.org/2001/XMLSchema#string

Isabelle Frappa

http://www.w3.org/2001/XMLSchema#string

Judith Baumeister

http://www.w3.org/2001/XMLSchema#string

Jutta Mäben

http://www.w3.org/2001/XMLSchema#string

P2860

9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group

Antiviral agents for non-human immunodeficiency virus infections.

Helicase motifs: the engine that powers DNA unwinding.

Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

Growth inhibition by acycloguanosine of herpesviruses isolated from human infections.

Herpes simplex virus DNA replication.

A quantitative study of the effects of several nucleoside analogues on established herpes encephalitis in mice.

P2888

P304

392-398

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NM0402-392

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

8

http://www.w3.org/2001/XMLSchema#string

P50

Helga Rübsamen-Waigmann

P577

2002-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

11927946

http://www.w3.org/2001/XMLSchema#string