Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
about
Protease inhibition as new therapeutic strategy for GI diseasesStructural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsinDeterminants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with MesotrypsinPresence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitorsSerine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behaviorMesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as SubstratesNew quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains.Evolution of primary hemostasis in early vertebratesThe amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.Small molecule inhibitors of mesotrypsin from a structure-based docking screen.Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cellsProteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.Proteinase-activated receptor-2 up-regulation by Fcgamma-receptor activation in human neutrophilsDifferential proteomic analysis of the pancreas of diabetic db/db mice reveals the proteins involved in the development of complications of diabetes mellitus.Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptorsTransient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in miceNeutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)Proteinase-activated receptor-1 mediates dorsal root ganglion neuronal degeneration in HIV/AIDS.Modulation of protease-activated receptor expression by Porphyromonas gingivalis in human gingival epithelial cells.New insights into protease-activated receptor 4 signaling pathways in the pathogenesis of inflammation and neuropathic pain: a literature reviewCockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancerProtease-activated receptor (PAR)1, PAR2 and PAR4 expressions in esophageal squamous cell carcinoma.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.Serine proteases mediate inflammatory pain in acute pancreatitis.Biochemical and structural insights into mesotrypsin: an unusual human trypsin.Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice.Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.Biased signaling of protease-activated receptors.Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2.Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.Chemical and molecular factors in irritable bowel syndrome: current knowledge, challenges, and unanswered questions.Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).Epithelial expression and function of trypsin-3 in irritable bowel syndrome.Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.Dabigatran potentiates gemcitabine-induced growth inhibition of pancreatic cancer in mice.
P2860
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P2860
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@ast
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@en
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@nl
type
label
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@ast
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@en
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@nl
prefLabel
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@ast
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@en
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@nl
P2093
P356
P1476
Trypsin IV or mesotrypsin and ...... inflammation and hyperalgesia.
@en
P2093
Anders Peterson
Anita Skåregärde
Graeme S Cottrell
Johanna Mohlin
Karin Gedda
Kevin Chapman
Morley D Hollenberg
Nigel W Bunnett
Silvia Amadesi
Wolfgang Knecht
P304
26089-26100
P356
10.1074/JBC.M703840200
P407
P577
2007-07-10T00:00:00Z